Anti-HV323/ IGHV3-23/ DP47 monoclonal antibody

Anti-HV323/ IGHV3-23/ DP47 antibody for FACS & in-vivo assay

Target products collectionGo to IGHV3-23/IGHV3-23 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2446-Ab-1/ GM-Tg-hg-MP2446-Ab-2Anti-Human IGHV3-23 monoclonal antibodyHuman
GM-Tg-rg-MP2446-Ab-1/ GM-Tg-rg-MP2446-Ab-2Anti-Rat IGHV3-23 monoclonal antibodyRat
GM-Tg-mg-MP2446-Ab-1/ GM-Tg-mg-MP2446-Ab-2Anti-Mouse IGHV3-23 monoclonal antibodyMouse
GM-Tg-cynog-MP2446-Ab-1/ GM-Tg-cynog-MP2446-Ab-2Anti-Cynomolgus/ Rhesus macaque IGHV3-23 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2446-Ab-1/ GM-Tg-felg-MP2446-Ab-2Anti-Feline IGHV3-23 monoclonal antibodyFeline
GM-Tg-cang-MP2446-Ab-1/ GM-Tg-cang-MP2446-Ab-2Anti-Canine IGHV3-23 monoclonal antibodyCanine
GM-Tg-bovg-MP2446-Ab-1/ GM-Tg-bovg-MP2446-Ab-2Anti-Bovine IGHV3-23 monoclonal antibodyBovine
GM-Tg-equg-MP2446-Ab-1/ GM-Tg-equg-MP2446-Ab-2Anti-Equine IGHV3-23 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2446-Ab-1/ GM-Tg-hg-MP2446-Ab-2; GM-Tg-rg-MP2446-Ab-1/ GM-Tg-rg-MP2446-Ab-2;
GM-Tg-mg-MP2446-Ab-1/ GM-Tg-mg-MP2446-Ab-2; GM-Tg-cynog-MP2446-Ab-1/ GM-Tg-cynog-MP2446-Ab-2;
GM-Tg-felg-MP2446-Ab-1/ GM-Tg-felg-MP2446-Ab-2; GM-Tg-cang-MP2446-Ab-1/ GM-Tg-cang-MP2446-Ab-2;
GM-Tg-bovg-MP2446-Ab-1/ GM-Tg-bovg-MP2446-Ab-2; GM-Tg-equg-MP2446-Ab-1/ GM-Tg-equg-MP2446-Ab-2
Products NameAnti-IGHV3-23 monoclonal antibody
Formatmab
Target NameIGHV3-23
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-IGHV3-23 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species HV323/ IGHV3-23/ DP47 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2446
    Target NameIGHV3-23
    Gene ID28442
    Gene Symbol and SynonymsDP47,IGHV3-23,IGHV323,V3-23,VH26
    Uniprot AccessionP01764
    Uniprot Entry NameHV323_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000211949
    Target ClassificationN/A

    The target: IGHV3-23, gene name: IGHV3-23, also named as DP47, IGHV323, V3-23, VH26. IGHV3-23 belongs to a cluster of approximately 40 functional variable (V) genes in the immunoglobulin (Ig) heavy chain locus on chromosome 14. For background information on the Ig heavy chain and the V gene cluster, see (MIM 147070).[supplied by OMIM, Apr 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.