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Anti-ITIH4/ GP120/ H4P monoclonal antibody
Anti-ITIH4/ GP120/ H4P antibody for FACS & in-vivo assay
Go to ITIH4/ITIH4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2546-Ab-1/ GM-Tg-hg-MP2546-Ab-2 | Anti-Human ITIH4 monoclonal antibody | Human |
| GM-Tg-rg-MP2546-Ab-1/ GM-Tg-rg-MP2546-Ab-2 | Anti-Rat ITIH4 monoclonal antibody | Rat |
| GM-Tg-mg-MP2546-Ab-1/ GM-Tg-mg-MP2546-Ab-2 | Anti-Mouse ITIH4 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2546-Ab-1/ GM-Tg-cynog-MP2546-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ITIH4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2546-Ab-1/ GM-Tg-felg-MP2546-Ab-2 | Anti-Feline ITIH4 monoclonal antibody | Feline |
| GM-Tg-cang-MP2546-Ab-1/ GM-Tg-cang-MP2546-Ab-2 | Anti-Canine ITIH4 monoclonal antibody | Canine |
| GM-Tg-bovg-MP2546-Ab-1/ GM-Tg-bovg-MP2546-Ab-2 | Anti-Bovine ITIH4 monoclonal antibody | Bovine |
| GM-Tg-equg-MP2546-Ab-1/ GM-Tg-equg-MP2546-Ab-2 | Anti-Equine ITIH4 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2546-Ab-1/ GM-Tg-hg-MP2546-Ab-2; GM-Tg-rg-MP2546-Ab-1/ GM-Tg-rg-MP2546-Ab-2; GM-Tg-mg-MP2546-Ab-1/ GM-Tg-mg-MP2546-Ab-2; GM-Tg-cynog-MP2546-Ab-1/ GM-Tg-cynog-MP2546-Ab-2; GM-Tg-felg-MP2546-Ab-1/ GM-Tg-felg-MP2546-Ab-2; GM-Tg-cang-MP2546-Ab-1/ GM-Tg-cang-MP2546-Ab-2; GM-Tg-bovg-MP2546-Ab-1/ GM-Tg-bovg-MP2546-Ab-2; GM-Tg-equg-MP2546-Ab-1/ GM-Tg-equg-MP2546-Ab-2 |
| Products Name | Anti-ITIH4 monoclonal antibody |
| Format | mab |
| Target Name | ITIH4 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ITIH4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species ITIH4/ GP120/ H4P VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP001672 | human ITIH4 Lentivirus particle |
| ORF Viral Vector | pGMLP001672 | human ITIH4 Lentivirus plasmid |
Target information
| Target ID | GM-MP2546 |
| Target Name | ITIH4 |
| Gene ID | 3700,16427,54404,695305,607088,101093423,513700,100059906 |
| Gene Symbol and Synonyms | GP120,H4P,IHRP,ITI-HC4,Itih-4,ITIH4,ITIHL1,PK-120,PK120 |
| Uniprot Accession | Q14624,Q3T052 |
| Uniprot Entry Name | ITIH4_HUMAN,ITIH4_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Ovary Cancer, Interstitial cystitis (chronic), Contact with and (suspected) exposure to environmental tobacco smoke (acute) (chronic), IgA glomerulonephritis, Ovarian cancer, Type 2 diabetes mellitus with diabetic nephropathy |
| Gene Ensembl | ENSG00000055955 |
| Target Classification | N/A |
The target: ITIH4, gene name: ITIH4, also named as GP120, H4P, IHRP, ITI-HC4, ITIHL1, PK-120, PK120. The protein encoded by this gene is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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