- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-PHLP1/ PHLPP1/ PHLPP monoclonal antibody
Anti-PHLP1/ PHLPP1/ PHLPP antibody for FACS & in-vivo assay
Go to PHLPP1/PHLPP1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2577-Ab-1/ GM-Tg-hg-MP2577-Ab-2 | Anti-Human PHLPP1 monoclonal antibody | Human |
| GM-Tg-rg-MP2577-Ab-1/ GM-Tg-rg-MP2577-Ab-2 | Anti-Rat PHLPP1 monoclonal antibody | Rat |
| GM-Tg-mg-MP2577-Ab-1/ GM-Tg-mg-MP2577-Ab-2 | Anti-Mouse PHLPP1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2577-Ab-1/ GM-Tg-cynog-MP2577-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PHLPP1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2577-Ab-1/ GM-Tg-felg-MP2577-Ab-2 | Anti-Feline PHLPP1 monoclonal antibody | Feline |
| GM-Tg-cang-MP2577-Ab-1/ GM-Tg-cang-MP2577-Ab-2 | Anti-Canine PHLPP1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP2577-Ab-1/ GM-Tg-bovg-MP2577-Ab-2 | Anti-Bovine PHLPP1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP2577-Ab-1/ GM-Tg-equg-MP2577-Ab-2 | Anti-Equine PHLPP1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2577-Ab-1/ GM-Tg-hg-MP2577-Ab-2; GM-Tg-rg-MP2577-Ab-1/ GM-Tg-rg-MP2577-Ab-2; GM-Tg-mg-MP2577-Ab-1/ GM-Tg-mg-MP2577-Ab-2; GM-Tg-cynog-MP2577-Ab-1/ GM-Tg-cynog-MP2577-Ab-2; GM-Tg-felg-MP2577-Ab-1/ GM-Tg-felg-MP2577-Ab-2; GM-Tg-cang-MP2577-Ab-1/ GM-Tg-cang-MP2577-Ab-2; GM-Tg-bovg-MP2577-Ab-1/ GM-Tg-bovg-MP2577-Ab-2; GM-Tg-equg-MP2577-Ab-1/ GM-Tg-equg-MP2577-Ab-2 |
| Products Name | Anti-PHLPP1 monoclonal antibody |
| Format | mab |
| Target Name | PHLPP1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PHLPP1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species PHLP1/ PHLPP1/ PHLPP VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMAD000373 | mouse Phlpp1 Adenovirus plasmid |
| ORF Viral Vector | vGMAD000373 | mouse Phlpp1 Adenovirus particle |
Target information
| Target ID | GM-MP2577 |
| Target Name | PHLPP1 |
| Gene ID | 23239,98432,59265,705882,476179,101091156,615982,100057142 |
| Gene Symbol and Synonyms | mKIAA0606,PHLPP,PHLPP1,PLEKHE1,PPM3A,SCOP |
| Uniprot Accession | O60346,Q9WTR8 |
| Uniprot Entry Name | PHLP1_HUMAN,PHLP1_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000081913 |
| Target Classification | N/A |
The target: PHLPP1, gene name: PHLPP1, also named as PHLPP, PLEKHE1, PPM3A, SCOP. This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. [provided by RefSeq, Dec 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
