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Anti-CP2CI/ CYP2C18/ CPCI monoclonal antibody
Anti-CP2CI/ CYP2C18/ CPCI antibody for FACS & in-vivo assay
Go to CYP2C18/CYP2C18 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2582-Ab-1/ GM-Tg-hg-MP2582-Ab-2 | Anti-Human CYP2C18 monoclonal antibody | Human |
| GM-Tg-rg-MP2582-Ab-1/ GM-Tg-rg-MP2582-Ab-2 | Anti-Rat CYP2C18 monoclonal antibody | Rat |
| GM-Tg-mg-MP2582-Ab-1/ GM-Tg-mg-MP2582-Ab-2 | Anti-Mouse CYP2C18 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2582-Ab-1/ GM-Tg-cynog-MP2582-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CYP2C18 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2582-Ab-1/ GM-Tg-felg-MP2582-Ab-2 | Anti-Feline CYP2C18 monoclonal antibody | Feline |
| GM-Tg-cang-MP2582-Ab-1/ GM-Tg-cang-MP2582-Ab-2 | Anti-Canine CYP2C18 monoclonal antibody | Canine |
| GM-Tg-bovg-MP2582-Ab-1/ GM-Tg-bovg-MP2582-Ab-2 | Anti-Bovine CYP2C18 monoclonal antibody | Bovine |
| GM-Tg-equg-MP2582-Ab-1/ GM-Tg-equg-MP2582-Ab-2 | Anti-Equine CYP2C18 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2582-Ab-1/ GM-Tg-hg-MP2582-Ab-2; GM-Tg-rg-MP2582-Ab-1/ GM-Tg-rg-MP2582-Ab-2; GM-Tg-mg-MP2582-Ab-1/ GM-Tg-mg-MP2582-Ab-2; GM-Tg-cynog-MP2582-Ab-1/ GM-Tg-cynog-MP2582-Ab-2; GM-Tg-felg-MP2582-Ab-1/ GM-Tg-felg-MP2582-Ab-2; GM-Tg-cang-MP2582-Ab-1/ GM-Tg-cang-MP2582-Ab-2; GM-Tg-bovg-MP2582-Ab-1/ GM-Tg-bovg-MP2582-Ab-2; GM-Tg-equg-MP2582-Ab-1/ GM-Tg-equg-MP2582-Ab-2 |
| Products Name | Anti-CYP2C18 monoclonal antibody |
| Format | mab |
| Target Name | CYP2C18 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CYP2C18 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CP2CI/ CYP2C18/ CPCI VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP000733 | human CYP2C18 Lentivirus plasmid |
| ORF Viral Vector | vGMLP000733 | human CYP2C18 Lentivirus particle |
Target information
| Target ID | GM-MP2582 |
| Target Name | CYP2C18 |
| Gene ID | 1562,701855 |
| Gene Symbol and Synonyms | CPCI,CYP2C,CYP2C17,CYP2C18,P450-6B/29C,P450IIC17 |
| Uniprot Accession | P33260 |
| Uniprot Entry Name | CP2CI_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000108242 |
| Target Classification | N/A |
The target: CYP2C18, gene name: CYP2C18, also named as CPCI, CYP2C, CYP2C17, P450-6B/29C, P450IIC17. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP2C17 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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