Anti-MCF2L/ ARHGEF14/ DBS monoclonal antibody

Anti-MCF2L/ ARHGEF14/ DBS antibody for FACS & in-vivo assay

Target products collectionGo to MCF2L/MCF2L products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2588-Ab-1/ GM-Tg-hg-MP2588-Ab-2Anti-Human MCF2L monoclonal antibodyHuman
GM-Tg-rg-MP2588-Ab-1/ GM-Tg-rg-MP2588-Ab-2Anti-Rat MCF2L monoclonal antibodyRat
GM-Tg-mg-MP2588-Ab-1/ GM-Tg-mg-MP2588-Ab-2Anti-Mouse MCF2L monoclonal antibodyMouse
GM-Tg-cynog-MP2588-Ab-1/ GM-Tg-cynog-MP2588-Ab-2Anti-Cynomolgus/ Rhesus macaque MCF2L monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2588-Ab-1/ GM-Tg-felg-MP2588-Ab-2Anti-Feline MCF2L monoclonal antibodyFeline
GM-Tg-cang-MP2588-Ab-1/ GM-Tg-cang-MP2588-Ab-2Anti-Canine MCF2L monoclonal antibodyCanine
GM-Tg-bovg-MP2588-Ab-1/ GM-Tg-bovg-MP2588-Ab-2Anti-Bovine MCF2L monoclonal antibodyBovine
GM-Tg-equg-MP2588-Ab-1/ GM-Tg-equg-MP2588-Ab-2Anti-Equine MCF2L monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2588-Ab-1/ GM-Tg-hg-MP2588-Ab-2; GM-Tg-rg-MP2588-Ab-1/ GM-Tg-rg-MP2588-Ab-2;
GM-Tg-mg-MP2588-Ab-1/ GM-Tg-mg-MP2588-Ab-2; GM-Tg-cynog-MP2588-Ab-1/ GM-Tg-cynog-MP2588-Ab-2;
GM-Tg-felg-MP2588-Ab-1/ GM-Tg-felg-MP2588-Ab-2; GM-Tg-cang-MP2588-Ab-1/ GM-Tg-cang-MP2588-Ab-2;
GM-Tg-bovg-MP2588-Ab-1/ GM-Tg-bovg-MP2588-Ab-2; GM-Tg-equg-MP2588-Ab-1/ GM-Tg-equg-MP2588-Ab-2
Products NameAnti-MCF2L monoclonal antibody
Formatmab
Target NameMCF2L
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-MCF2L benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species MCF2L/ ARHGEF14/ DBS VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2588
    Target NameMCF2L
    Gene ID23263,17207,117020,713961,485555,101090322,505595,100067048
    Gene Symbol and SynonymsARHGEF14,C130040G20Rik,DBS,mcf 2l,MCF2L,mKIAA0362,OST
    Uniprot AccessionO15068,Q63406
    Uniprot Entry NameMCF2L_HUMAN,MCF2L_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000126217
    Target ClassificationN/A

    The target: MCF2L, gene name: MCF2L, also named as ARHGEF14, DBS, OST. This gene encodes a guanine nucleotide exchange factor that interacts specifically with the GTP-bound Rac1 and plays a role in the Rho/Rac signaling pathways. A variant in this gene was associated with osteoarthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.