Anti-RGDSR/ RGL4/ Rgr monoclonal antibody

Anti-RGDSR/ RGL4/ Rgr antibody for FACS & in-vivo assay

Target products collectionGo to RGL4/RGL4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2595-Ab-1/ GM-Tg-hg-MP2595-Ab-2Anti-Human RGL4 monoclonal antibodyHuman
GM-Tg-rg-MP2595-Ab-1/ GM-Tg-rg-MP2595-Ab-2Anti-Rat RGL4 monoclonal antibodyRat
GM-Tg-mg-MP2595-Ab-1/ GM-Tg-mg-MP2595-Ab-2Anti-Mouse RGL4 monoclonal antibodyMouse
GM-Tg-cynog-MP2595-Ab-1/ GM-Tg-cynog-MP2595-Ab-2Anti-Cynomolgus/ Rhesus macaque RGL4 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2595-Ab-1/ GM-Tg-felg-MP2595-Ab-2Anti-Feline RGL4 monoclonal antibodyFeline
GM-Tg-cang-MP2595-Ab-1/ GM-Tg-cang-MP2595-Ab-2Anti-Canine RGL4 monoclonal antibodyCanine
GM-Tg-bovg-MP2595-Ab-1/ GM-Tg-bovg-MP2595-Ab-2Anti-Bovine RGL4 monoclonal antibodyBovine
GM-Tg-equg-MP2595-Ab-1/ GM-Tg-equg-MP2595-Ab-2Anti-Equine RGL4 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2595-Ab-1/ GM-Tg-hg-MP2595-Ab-2; GM-Tg-rg-MP2595-Ab-1/ GM-Tg-rg-MP2595-Ab-2;
GM-Tg-mg-MP2595-Ab-1/ GM-Tg-mg-MP2595-Ab-2; GM-Tg-cynog-MP2595-Ab-1/ GM-Tg-cynog-MP2595-Ab-2;
GM-Tg-felg-MP2595-Ab-1/ GM-Tg-felg-MP2595-Ab-2; GM-Tg-cang-MP2595-Ab-1/ GM-Tg-cang-MP2595-Ab-2;
GM-Tg-bovg-MP2595-Ab-1/ GM-Tg-bovg-MP2595-Ab-2; GM-Tg-equg-MP2595-Ab-1/ GM-Tg-equg-MP2595-Ab-2
Products NameAnti-RGL4 monoclonal antibody
Formatmab
Target NameRGL4
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-RGL4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species RGDSR/ RGL4/ Rgr VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2595
    Target NameRGL4
    Gene ID266747
    Gene Symbol and SynonymsRGL4,Rgr
    Uniprot AccessionQ8IZJ4
    Uniprot Entry NameRGDSR_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000159496
    Target ClassificationN/A

    The target: RGL4, gene name: RGL4, also named as Rgr. This oncogene encodes a protein similar to guanine nucleotide exchange factor Ral guanine dissociation stimulator. Increased expression of this gene leads to translocation of the encoded protein to the cell membrane. The encoded protein can activate several pathways, including the Ras-Raf-MEK-ERK cascade. [provided by RefSeq, Jul 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.