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Anti-CMGA/ CHGA/ CGA functional antibody
Anti-CMGA/ CHGA/ CGA functional antibody for cell culture, ELISA & in-vivo assay
Go to CHGA/CHGA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0080-Ab-1/ GM-Tg-hg-SE0080-Ab-2 | Anti-Human CHGA monoclonal antibody | Human |
| GM-Tg-rg-SE0080-Ab-1/ GM-Tg-rg-SE0080-Ab-2 | Anti-Rat CHGA monoclonal antibody | Rat |
| GM-Tg-mg-SE0080-Ab-1/ GM-Tg-mg-SE0080-Ab-2 | Anti-Mouse CHGA monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0080-Ab-1/ GM-Tg-cynog-SE0080-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CHGA monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0080-Ab-1/ GM-Tg-felg-SE0080-Ab-2 | Anti-Feline CHGA monoclonal antibody | Feline |
| GM-Tg-cang-SE0080-Ab-1/ GM-Tg-cang-SE0080-Ab-2 | Anti-Canine CHGA monoclonal antibody | Canine |
| GM-Tg-bovg-SE0080-Ab-1/ GM-Tg-bovg-SE0080-Ab-2 | Anti-Bovine CHGA monoclonal antibody | Bovine |
| GM-Tg-equg-SE0080-Ab-1/ GM-Tg-equg-SE0080-Ab-2 | Anti-Equine CHGA monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0080-Ab-1/ GM-Tg-hg-SE0080-Ab-2; GM-Tg-rg-SE0080-Ab-1/ GM-Tg-rg-SE0080-Ab-2; GM-Tg-mg-SE0080-Ab-1/ GM-Tg-mg-SE0080-Ab-2; GM-Tg-cynog-SE0080-Ab-1/ GM-Tg-cynog-SE0080-Ab-2; GM-Tg-felg-SE0080-Ab-1/ GM-Tg-felg-SE0080-Ab-2; GM-Tg-cang-SE0080-Ab-1/ GM-Tg-cang-SE0080-Ab-2; GM-Tg-bovg-SE0080-Ab-1/ GM-Tg-bovg-SE0080-Ab-2; GM-Tg-equg-SE0080-Ab-1/ GM-Tg-equg-SE0080-Ab-2 |
| Products Name | Anti-CHGA monoclonal antibody |
| Format | mab |
| Target Name | CHGA |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CHGA benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0080-Ag-1 | Recombinant multi-species CMGA/ CHGA/ CGA protein |
| ORF Viral Vector | pGMAP000499 | Human CHGA Adenovirus plasmid |
| ORF Viral Vector | vGMAP000499 | Human CHGA Adenovirus particle |
| ORF Viral Vector | pGMLPm002343 | mouse Chga Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002343 | mouse Chga Lentivirus particle |
Target information
| Target ID | GM-SE0080 |
| Target Name | CHGA |
| Gene ID | 1113,12652,24258,574388,607527,101087412,281070,111770391 |
| Gene Symbol and Synonyms | CGA,CHGA,ChrA,PHE5,PHES |
| Uniprot Accession | P10645,P10354,P05059 |
| Uniprot Entry Name | CMGA_HUMAN,CMGA_RAT,CMGA_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | Breast Cancer, neuroen docrine |
| Gene Ensembl | ENSG00000100604 |
| Target Classification | N/A |
The target: CHGA, gene name: CHGA, also named as CGA. The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two other peptides, catestatin and chromofungin, have antimicrobial activity and antifungal activity, respectively. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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