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Anti-COL/ CLPS functional antibody
Anti-COL/ CLPS functional antibody for cell culture, ELISA & in-vivo assay
Go to CLPS/CLPS products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0095-Ab-1/ GM-Tg-hg-SE0095-Ab-2 | Anti-Human CLPS monoclonal antibody | Human |
| GM-Tg-rg-SE0095-Ab-1/ GM-Tg-rg-SE0095-Ab-2 | Anti-Rat CLPS monoclonal antibody | Rat |
| GM-Tg-mg-SE0095-Ab-1/ GM-Tg-mg-SE0095-Ab-2 | Anti-Mouse CLPS monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0095-Ab-1/ GM-Tg-cynog-SE0095-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CLPS monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0095-Ab-1/ GM-Tg-felg-SE0095-Ab-2 | Anti-Feline CLPS monoclonal antibody | Feline |
| GM-Tg-cang-SE0095-Ab-1/ GM-Tg-cang-SE0095-Ab-2 | Anti-Canine CLPS monoclonal antibody | Canine |
| GM-Tg-bovg-SE0095-Ab-1/ GM-Tg-bovg-SE0095-Ab-2 | Anti-Bovine CLPS monoclonal antibody | Bovine |
| GM-Tg-equg-SE0095-Ab-1/ GM-Tg-equg-SE0095-Ab-2 | Anti-Equine CLPS monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0095-Ab-1/ GM-Tg-hg-SE0095-Ab-2; GM-Tg-rg-SE0095-Ab-1/ GM-Tg-rg-SE0095-Ab-2; GM-Tg-mg-SE0095-Ab-1/ GM-Tg-mg-SE0095-Ab-2; GM-Tg-cynog-SE0095-Ab-1/ GM-Tg-cynog-SE0095-Ab-2; GM-Tg-felg-SE0095-Ab-1/ GM-Tg-felg-SE0095-Ab-2; GM-Tg-cang-SE0095-Ab-1/ GM-Tg-cang-SE0095-Ab-2; GM-Tg-bovg-SE0095-Ab-1/ GM-Tg-bovg-SE0095-Ab-2; GM-Tg-equg-SE0095-Ab-1/ GM-Tg-equg-SE0095-Ab-2 |
| Products Name | Anti-CLPS monoclonal antibody |
| Format | mab |
| Target Name | CLPS |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CLPS benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0095-Ag-1 | Recombinant multi-species COL/ CLPS protein |
| ORF Viral Vector | vGMLP000077 | human CLPS Lentivirus particle |
| ORF Viral Vector | pGMLP000077 | human CLPS Lentivirus plasmid |
| ORF Viral Vector | pGMLPm000542 | mouse Clps Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000542 | mouse Clps Lentivirus particle |
Target information
| Target ID | GM-SE0095 |
| Target Name | CLPS |
| Gene ID | 1208,109791,25680,719005,403970,101100391,525923,100053646 |
| Gene Symbol and Synonyms | 2200003J09Rik,CLPS,CLPS1,CLPS2,COLQ |
| Uniprot Accession | P04118,P17084,P19090,A0JNQ7,P02704,P02705 |
| Uniprot Entry Name | COL_HUMAN,COL_RAT,COL_CANLF,COL_BOVIN,COLA_HORSE,COLB_HORSE |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000137392 |
| Target Classification | N/A |
The target: CLPS, gene name: CLPS, also named as . The protein encoded by this gene is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilizing an active conformation and considerably increasing the overall hydrophobic binding site. The gene product allows lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. This cofactor is only expressed in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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