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Anti-DNS2B/ DNASE2B/ DLAD functional antibody
Anti-DNS2B/ DNASE2B/ DLAD functional antibody for cell culture, ELISA & in-vivo assay
Go to DNASE2B/DNASE2B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0161-Ab-1/ GM-Tg-hg-SE0161-Ab-2 | Anti-Human DNASE2B monoclonal antibody | Human |
| GM-Tg-rg-SE0161-Ab-1/ GM-Tg-rg-SE0161-Ab-2 | Anti-Rat DNASE2B monoclonal antibody | Rat |
| GM-Tg-mg-SE0161-Ab-1/ GM-Tg-mg-SE0161-Ab-2 | Anti-Mouse DNASE2B monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0161-Ab-1/ GM-Tg-cynog-SE0161-Ab-2 | Anti-Cynomolgus/ Rhesus macaque DNASE2B monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0161-Ab-1/ GM-Tg-felg-SE0161-Ab-2 | Anti-Feline DNASE2B monoclonal antibody | Feline |
| GM-Tg-cang-SE0161-Ab-1/ GM-Tg-cang-SE0161-Ab-2 | Anti-Canine DNASE2B monoclonal antibody | Canine |
| GM-Tg-bovg-SE0161-Ab-1/ GM-Tg-bovg-SE0161-Ab-2 | Anti-Bovine DNASE2B monoclonal antibody | Bovine |
| GM-Tg-equg-SE0161-Ab-1/ GM-Tg-equg-SE0161-Ab-2 | Anti-Equine DNASE2B monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0161-Ab-1/ GM-Tg-hg-SE0161-Ab-2; GM-Tg-rg-SE0161-Ab-1/ GM-Tg-rg-SE0161-Ab-2; GM-Tg-mg-SE0161-Ab-1/ GM-Tg-mg-SE0161-Ab-2; GM-Tg-cynog-SE0161-Ab-1/ GM-Tg-cynog-SE0161-Ab-2; GM-Tg-felg-SE0161-Ab-1/ GM-Tg-felg-SE0161-Ab-2; GM-Tg-cang-SE0161-Ab-1/ GM-Tg-cang-SE0161-Ab-2; GM-Tg-bovg-SE0161-Ab-1/ GM-Tg-bovg-SE0161-Ab-2; GM-Tg-equg-SE0161-Ab-1/ GM-Tg-equg-SE0161-Ab-2 |
| Products Name | Anti-DNASE2B monoclonal antibody |
| Format | mab |
| Target Name | DNASE2B |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-DNASE2B benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0161-Ag-1 | Recombinant multi-species DNS2B/ DNASE2B/ DLAD protein |
Target information
| Target ID | GM-SE0161 |
| Target Name | DNASE2B |
| Gene ID | 58511,56629,59296,710197,479973,101097005,525117,100064895 |
| Gene Symbol and Synonyms | DLAD,DNASE2B,DnaseIIb,UOX |
| Uniprot Accession | Q8WZ79,Q9QZK9 |
| Uniprot Entry Name | DNS2B_HUMAN,DNS2B_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000137976 |
| Target Classification | N/A |
The target: DNASE2B, gene name: DNASE2B, also named as DLAD. The protein encoded by this gene shares considerable sequence similarity to, and is structurally related to DNase II. The latter is a well characterized endonuclease that catalyzes DNA hydrolysis in the absence of divalent cations at acidic pH. Unlike DNase II which is ubiquitously expressed, expression of this gene product is restricted to the salivary gland and lungs. The gene has been localized to chromosome 1p22.3 adjacent (and in opposite orientation) to the uricase pseudogene. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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