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Anti-FILA2/ FLG2/ IFPS functional antibody
Anti-FILA2/ FLG2/ IFPS functional antibody for cell culture, ELISA & in-vivo assay
Go to FLG2/FLG2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0223-Ab-1/ GM-Tg-hg-SE0223-Ab-2 | Anti-Human FLG2 monoclonal antibody | Human |
| GM-Tg-rg-SE0223-Ab-1/ GM-Tg-rg-SE0223-Ab-2 | Anti-Rat FLG2 monoclonal antibody | Rat |
| GM-Tg-mg-SE0223-Ab-1/ GM-Tg-mg-SE0223-Ab-2 | Anti-Mouse FLG2 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0223-Ab-1/ GM-Tg-cynog-SE0223-Ab-2 | Anti-Cynomolgus/ Rhesus macaque FLG2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0223-Ab-1/ GM-Tg-felg-SE0223-Ab-2 | Anti-Feline FLG2 monoclonal antibody | Feline |
| GM-Tg-cang-SE0223-Ab-1/ GM-Tg-cang-SE0223-Ab-2 | Anti-Canine FLG2 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0223-Ab-1/ GM-Tg-bovg-SE0223-Ab-2 | Anti-Bovine FLG2 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0223-Ab-1/ GM-Tg-equg-SE0223-Ab-2 | Anti-Equine FLG2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0223-Ab-1/ GM-Tg-hg-SE0223-Ab-2; GM-Tg-rg-SE0223-Ab-1/ GM-Tg-rg-SE0223-Ab-2; GM-Tg-mg-SE0223-Ab-1/ GM-Tg-mg-SE0223-Ab-2; GM-Tg-cynog-SE0223-Ab-1/ GM-Tg-cynog-SE0223-Ab-2; GM-Tg-felg-SE0223-Ab-1/ GM-Tg-felg-SE0223-Ab-2; GM-Tg-cang-SE0223-Ab-1/ GM-Tg-cang-SE0223-Ab-2; GM-Tg-bovg-SE0223-Ab-1/ GM-Tg-bovg-SE0223-Ab-2; GM-Tg-equg-SE0223-Ab-1/ GM-Tg-equg-SE0223-Ab-2 |
| Products Name | Anti-FLG2 monoclonal antibody |
| Format | mab |
| Target Name | FLG2 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-FLG2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0223-Ag-1 | Recombinant multi-species FILA2/ FLG2/ IFPS protein |
Target information
| Target ID | GM-SE0223 |
| Target Name | FLG2 |
| Gene ID | 388698,717480 |
| Gene Symbol and Synonyms | FLG2,IFPS,PSS6 |
| Uniprot Accession | Q5D862 |
| Uniprot Entry Name | FILA2_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000143520 |
| Target Classification | N/A |
The target: FLG2, gene name: FLG2, also named as IFPS, PSS6. The filaggrin-like protein encoded by this gene is upregulated by calcium, proteolyzed by calpain 1, and is involved in epithelial homeostasis. The encoded protein is required for proper cornification in skin, with defects in this gene being associated with skin diseases. This protein also has a function in skin barrier protection. In fact, in addition to providing a physical barrier, C-terminal fragments of this protein display antimicrobial activity against P. aeruginosa and E. coli. [provided by RefSeq, Jul 2020].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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