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Anti-GRAH/ GZMH/ CCP-X functional antibody
Anti-GRAH/ GZMH/ CCP-X functional antibody for cell culture, ELISA & in-vivo assay
Go to GZMH/GZMH products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0253-Ab-1/ GM-Tg-hg-SE0253-Ab-2 | Anti-Human GZMH monoclonal antibody | Human |
| GM-Tg-rg-SE0253-Ab-1/ GM-Tg-rg-SE0253-Ab-2 | Anti-Rat GZMH monoclonal antibody | Rat |
| GM-Tg-mg-SE0253-Ab-1/ GM-Tg-mg-SE0253-Ab-2 | Anti-Mouse GZMH monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0253-Ab-1/ GM-Tg-cynog-SE0253-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GZMH monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0253-Ab-1/ GM-Tg-felg-SE0253-Ab-2 | Anti-Feline GZMH monoclonal antibody | Feline |
| GM-Tg-cang-SE0253-Ab-1/ GM-Tg-cang-SE0253-Ab-2 | Anti-Canine GZMH monoclonal antibody | Canine |
| GM-Tg-bovg-SE0253-Ab-1/ GM-Tg-bovg-SE0253-Ab-2 | Anti-Bovine GZMH monoclonal antibody | Bovine |
| GM-Tg-equg-SE0253-Ab-1/ GM-Tg-equg-SE0253-Ab-2 | Anti-Equine GZMH monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0253-Ab-1/ GM-Tg-hg-SE0253-Ab-2; GM-Tg-rg-SE0253-Ab-1/ GM-Tg-rg-SE0253-Ab-2; GM-Tg-mg-SE0253-Ab-1/ GM-Tg-mg-SE0253-Ab-2; GM-Tg-cynog-SE0253-Ab-1/ GM-Tg-cynog-SE0253-Ab-2; GM-Tg-felg-SE0253-Ab-1/ GM-Tg-felg-SE0253-Ab-2; GM-Tg-cang-SE0253-Ab-1/ GM-Tg-cang-SE0253-Ab-2; GM-Tg-bovg-SE0253-Ab-1/ GM-Tg-bovg-SE0253-Ab-2; GM-Tg-equg-SE0253-Ab-1/ GM-Tg-equg-SE0253-Ab-2 |
| Products Name | Anti-GZMH monoclonal antibody |
| Format | mab |
| Target Name | GZMH |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-GZMH benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0253-Ag-1 | Recombinant multi-species GRAH/ GZMH/ CCP-X protein |
| ORF Viral Vector | pGMLPm004676 | mouse Gzme Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004676 | mouse Gzme Lentivirus particle |
Target information
| Target ID | GM-SE0253 |
| Target Name | GZMH |
| Gene ID | 2999,14940,715108 |
| Gene Symbol and Synonyms | B10,CCP-X,CCP2,CGL-2,CSP-C,Ctla-5,CTLA1,Ctla5,CTSGL2,Gzmc,GZMH |
| Uniprot Accession | P20718 |
| Uniprot Entry Name | GRAH_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000100450 |
| Target Classification | N/A |
The target: GZMH, gene name: GZMH, also named as CCP-X, CGL-2, CSP-C, CTLA1, CTSGL2. This gene encodes a member of the peptidase S1 family of serine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a chymotrypsin-like protease. This protein is reported to be constitutively expressed in the NK (natural killer) cells of the immune system and may play a role in the cytotoxic arm of the innate immune response by inducing target cell death and by directly cleaving substrates in pathogen-infected cells. This gene is present in a gene cluster with another member of the granzyme subfamily on chromosome 14. [provided by RefSeq, Nov 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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