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Anti-ANF/ NPPA/ ANP functional antibody
Anti-ANF/ NPPA/ ANP functional antibody for cell culture, ELISA & in-vivo assay
Go to NPPA/NPPA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0373-Ab-1/ GM-Tg-hg-SE0373-Ab-2 | Anti-Human NPPA monoclonal antibody | Human |
| GM-Tg-rg-SE0373-Ab-1/ GM-Tg-rg-SE0373-Ab-2 | Anti-Rat NPPA monoclonal antibody | Rat |
| GM-Tg-mg-SE0373-Ab-1/ GM-Tg-mg-SE0373-Ab-2 | Anti-Mouse NPPA monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0373-Ab-1/ GM-Tg-cynog-SE0373-Ab-2 | Anti-Cynomolgus/ Rhesus macaque NPPA monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0373-Ab-1/ GM-Tg-felg-SE0373-Ab-2 | Anti-Feline NPPA monoclonal antibody | Feline |
| GM-Tg-cang-SE0373-Ab-1/ GM-Tg-cang-SE0373-Ab-2 | Anti-Canine NPPA monoclonal antibody | Canine |
| GM-Tg-bovg-SE0373-Ab-1/ GM-Tg-bovg-SE0373-Ab-2 | Anti-Bovine NPPA monoclonal antibody | Bovine |
| GM-Tg-equg-SE0373-Ab-1/ GM-Tg-equg-SE0373-Ab-2 | Anti-Equine NPPA monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0373-Ab-1/ GM-Tg-hg-SE0373-Ab-2; GM-Tg-rg-SE0373-Ab-1/ GM-Tg-rg-SE0373-Ab-2; GM-Tg-mg-SE0373-Ab-1/ GM-Tg-mg-SE0373-Ab-2; GM-Tg-cynog-SE0373-Ab-1/ GM-Tg-cynog-SE0373-Ab-2; GM-Tg-felg-SE0373-Ab-1/ GM-Tg-felg-SE0373-Ab-2; GM-Tg-cang-SE0373-Ab-1/ GM-Tg-cang-SE0373-Ab-2; GM-Tg-bovg-SE0373-Ab-1/ GM-Tg-bovg-SE0373-Ab-2; GM-Tg-equg-SE0373-Ab-1/ GM-Tg-equg-SE0373-Ab-2 |
| Products Name | Anti-NPPA monoclonal antibody |
| Format | mab |
| Target Name | NPPA |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Diagnostic target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-NPPA benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0373-Ag-1 | Recombinant multi-species ANF/ NPPA/ ANP protein |
| ORF Viral Vector | vGMLP000970 | human NPPA Lentivirus particle |
| ORF Viral Vector | pGMLP000970 | human NPPA Lentivirus plasmid |
| ORF Viral Vector | pGMLPm000826 | mouse Nppa Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000826 | mouse Nppa Lentivirus particle |
Target information
| Target ID | GM-SE0373 |
| Target Name | NPPA |
| Gene ID | 4878,230899,24602,714994,608289,101100575,281355,100034201 |
| Gene Symbol and Synonyms | ANF,ANP,ATFB6,ATRST2,CDD,CDD-ANF,CDP,NPPA,PND,preproANF,preproANP,proANF,proANP,RATANF |
| Uniprot Accession | P01160,P01161,P07499,Q9GLD0,P07501,P27104 |
| Uniprot Entry Name | ANF_HUMAN,ANF_RAT,ANF_FELCA,ANF_CANLF,ANF_BOVIN,ANF_HORSE |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Diagnostics Biomarker |
| Disease | N/A |
| Gene Ensembl | ENSG00000175206 |
| Target Classification | N/A |
The target: NPPA, gene name: NPPA, also named as ANF, ANP, ATFB6, ATRST2, CDD, CDD-ANF, CDP, PND. The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. This gene is located adjacent to another member of the natriuretic family of peptides on chromosome 1. [provided by RefSeq, Oct 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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