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Anti-MIME/ OGN/ OG functional antibody
Anti-MIME/ OGN/ OG functional antibody for cell culture, ELISA & in-vivo assay
Go to OGN/OGN products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0384-Ab-1/ GM-Tg-hg-SE0384-Ab-2 | Anti-Human OGN monoclonal antibody | Human |
| GM-Tg-rg-SE0384-Ab-1/ GM-Tg-rg-SE0384-Ab-2 | Anti-Rat OGN monoclonal antibody | Rat |
| GM-Tg-mg-SE0384-Ab-1/ GM-Tg-mg-SE0384-Ab-2 | Anti-Mouse OGN monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0384-Ab-1/ GM-Tg-cynog-SE0384-Ab-2 | Anti-Cynomolgus/ Rhesus macaque OGN monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0384-Ab-1/ GM-Tg-felg-SE0384-Ab-2 | Anti-Feline OGN monoclonal antibody | Feline |
| GM-Tg-cang-SE0384-Ab-1/ GM-Tg-cang-SE0384-Ab-2 | Anti-Canine OGN monoclonal antibody | Canine |
| GM-Tg-bovg-SE0384-Ab-1/ GM-Tg-bovg-SE0384-Ab-2 | Anti-Bovine OGN monoclonal antibody | Bovine |
| GM-Tg-equg-SE0384-Ab-1/ GM-Tg-equg-SE0384-Ab-2 | Anti-Equine OGN monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0384-Ab-1/ GM-Tg-hg-SE0384-Ab-2; GM-Tg-rg-SE0384-Ab-1/ GM-Tg-rg-SE0384-Ab-2; GM-Tg-mg-SE0384-Ab-1/ GM-Tg-mg-SE0384-Ab-2; GM-Tg-cynog-SE0384-Ab-1/ GM-Tg-cynog-SE0384-Ab-2; GM-Tg-felg-SE0384-Ab-1/ GM-Tg-felg-SE0384-Ab-2; GM-Tg-cang-SE0384-Ab-1/ GM-Tg-cang-SE0384-Ab-2; GM-Tg-bovg-SE0384-Ab-1/ GM-Tg-bovg-SE0384-Ab-2; GM-Tg-equg-SE0384-Ab-1/ GM-Tg-equg-SE0384-Ab-2 |
| Products Name | Anti-OGN monoclonal antibody |
| Format | mab |
| Target Name | OGN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-OGN benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0384-Ag-1 | Recombinant multi-species MIME/ OGN/ OG protein |
| ORF Viral Vector | pGMAP000452 | Human OGN Adenovirus plasmid |
| ORF Viral Vector | vGMAP000452 | Human OGN Adenovirus particle |
| ORF Viral Vector | pGMAAV000375 | house mouse Ogn AAV plasmid |
| ORF Viral Vector | vGMAAV000375 | house mouse Ogn AAV particle |
Target information
| Target ID | GM-SE0384 |
| Target Name | OGN |
| Gene ID | 4969,18295,291015,706168,610704,102899607,280884,100054772 |
| Gene Symbol and Synonyms | 3110079A16Rik,mimecan,mimican,OG,OGN,OIF,SLRR3A |
| Uniprot Accession | P20774,P19879 |
| Uniprot Entry Name | MIME_HUMAN,MIME_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000106809 |
| Target Classification | N/A |
The target: OGN, gene name: OGN, also named as OG, OIF, SLRR3A. This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded protein induces ectopic bone formation in conjunction with transforming growth factor beta and may regulate osteoblast differentiation. High expression of the encoded protein may be associated with elevated heart left ventricular mass. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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