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Anti-ASC/ PYCARD/ CARD5 functional antibody
Anti-ASC/ PYCARD/ CARD5 functional antibody for cell culture, ELISA & in-vivo assay
Go to PYCARD/PYCARD products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0440-Ab-1/ GM-Tg-hg-SE0440-Ab-2 | Anti-Human PYCARD monoclonal antibody | Human |
| GM-Tg-rg-SE0440-Ab-1/ GM-Tg-rg-SE0440-Ab-2 | Anti-Rat PYCARD monoclonal antibody | Rat |
| GM-Tg-mg-SE0440-Ab-1/ GM-Tg-mg-SE0440-Ab-2 | Anti-Mouse PYCARD monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0440-Ab-1/ GM-Tg-cynog-SE0440-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PYCARD monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0440-Ab-1/ GM-Tg-felg-SE0440-Ab-2 | Anti-Feline PYCARD monoclonal antibody | Feline |
| GM-Tg-cang-SE0440-Ab-1/ GM-Tg-cang-SE0440-Ab-2 | Anti-Canine PYCARD monoclonal antibody | Canine |
| GM-Tg-bovg-SE0440-Ab-1/ GM-Tg-bovg-SE0440-Ab-2 | Anti-Bovine PYCARD monoclonal antibody | Bovine |
| GM-Tg-equg-SE0440-Ab-1/ GM-Tg-equg-SE0440-Ab-2 | Anti-Equine PYCARD monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0440-Ab-1/ GM-Tg-hg-SE0440-Ab-2; GM-Tg-rg-SE0440-Ab-1/ GM-Tg-rg-SE0440-Ab-2; GM-Tg-mg-SE0440-Ab-1/ GM-Tg-mg-SE0440-Ab-2; GM-Tg-cynog-SE0440-Ab-1/ GM-Tg-cynog-SE0440-Ab-2; GM-Tg-felg-SE0440-Ab-1/ GM-Tg-felg-SE0440-Ab-2; GM-Tg-cang-SE0440-Ab-1/ GM-Tg-cang-SE0440-Ab-2; GM-Tg-bovg-SE0440-Ab-1/ GM-Tg-bovg-SE0440-Ab-2; GM-Tg-equg-SE0440-Ab-1/ GM-Tg-equg-SE0440-Ab-2 |
| Products Name | Anti-PYCARD monoclonal antibody |
| Format | mab |
| Target Name | PYCARD |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PYCARD benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0440-Ag-1 | Recombinant multi-species ASC/ PYCARD/ CARD5 protein |
| ORF Viral Vector | pGMLP004754 | human PYCARD Lentivirus plasmid |
| ORF Viral Vector | vGMLP004754 | human PYCARD Lentivirus particle |
| ORF Viral Vector | pGMLPm000167 | mouse Pycard Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000167 | mouse Pycard Lentivirus particle |
Target information
| Target ID | GM-SE0440 |
| Target Name | PYCARD |
| Gene ID | 29108,713563 |
| Gene Symbol and Synonyms | ASC,CARD5,PYCARD,™S,™S-1,™S1 |
| Uniprot Accession | Q9ULZ3 |
| Uniprot Entry Name | ASC_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000103490 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: PYCARD, gene name: PYCARD, also named as ASC, CARD5, ™S, ™S-1, ™S1. This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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