Anti-RLA2/ RPLP2/ D11S2243E functional antibody

Anti-RLA2/ RPLP2/ D11S2243E functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to RPLP2/RPLP2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE0452-Ab-1/ GM-Tg-hg-SE0452-Ab-2Anti-Human RPLP2 monoclonal antibodyHuman
GM-Tg-rg-SE0452-Ab-1/ GM-Tg-rg-SE0452-Ab-2Anti-Rat RPLP2 monoclonal antibodyRat
GM-Tg-mg-SE0452-Ab-1/ GM-Tg-mg-SE0452-Ab-2Anti-Mouse RPLP2 monoclonal antibodyMouse
GM-Tg-cynog-SE0452-Ab-1/ GM-Tg-cynog-SE0452-Ab-2Anti-Cynomolgus/ Rhesus macaque RPLP2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE0452-Ab-1/ GM-Tg-felg-SE0452-Ab-2Anti-Feline RPLP2 monoclonal antibodyFeline
GM-Tg-cang-SE0452-Ab-1/ GM-Tg-cang-SE0452-Ab-2Anti-Canine RPLP2 monoclonal antibodyCanine
GM-Tg-bovg-SE0452-Ab-1/ GM-Tg-bovg-SE0452-Ab-2Anti-Bovine RPLP2 monoclonal antibodyBovine
GM-Tg-equg-SE0452-Ab-1/ GM-Tg-equg-SE0452-Ab-2Anti-Equine RPLP2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE0452-Ab-1/ GM-Tg-hg-SE0452-Ab-2; GM-Tg-rg-SE0452-Ab-1/ GM-Tg-rg-SE0452-Ab-2;
GM-Tg-mg-SE0452-Ab-1/ GM-Tg-mg-SE0452-Ab-2; GM-Tg-cynog-SE0452-Ab-1/ GM-Tg-cynog-SE0452-Ab-2;
GM-Tg-felg-SE0452-Ab-1/ GM-Tg-felg-SE0452-Ab-2; GM-Tg-cang-SE0452-Ab-1/ GM-Tg-cang-SE0452-Ab-2;
GM-Tg-bovg-SE0452-Ab-1/ GM-Tg-bovg-SE0452-Ab-2; GM-Tg-equg-SE0452-Ab-1/ GM-Tg-equg-SE0452-Ab-2
Products NameAnti-RPLP2 monoclonal antibody
Formatmab
Target NameRPLP2
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-RPLP2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE0452-Ag-1Recombinant multi-species RLA2/ RPLP2/ D11S2243E protein
    ORF Viral VectorpGMLP004212human RPLP2 Lentivirus plasmid
    ORF Viral VectorvGMLP004212human RPLP2 Lentivirus particle
    ORF Viral VectorpGMLPm003273mouse Rplp2 Lentivirus plasmid
    ORF Viral VectorvGMLPm003273mouse Rplp2 Lentivirus particle


    Target information

    Target IDGM-SE0452
    Target NameRPLP2
    Gene ID6181,67186,140662,700698,475991,101098579,286853,100034001
    Gene Symbol and Synonyms2700049I22Rik,D11S2243E,LP2,P2,RP2,RPLP2,RPP2
    Uniprot AccessionP05387,P02401,P42899,Q6X9Z5
    Uniprot Entry NameRLA2_HUMAN,RLA2_RAT,RLA2_BOVIN,RLA2_HORSE
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000177600
    Target ClassificationN/A

    The target: RPLP2, gene name: RPLP2, also named as D11S2243E, LP2, P2, RPP2. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal phosphoprotein that is a component of the 60S subunit. The protein, which is a functional equivalent of the E. coli L7/L12 ribosomal protein, belongs to the L12P family of ribosomal proteins. It plays an important role in the elongation step of protein synthesis. Unlike most ribosomal proteins, which are basic, the encoded protein is acidic. Its C-terminal end is nearly identical to the C-terminal ends of the ribosomal phosphoproteins P0 and P1. The P2 protein can interact with P0 and P1 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.