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Anti-AACT/ SERPINA3/ ACT functional antibody
Anti-AACT/ SERPINA3/ ACT functional antibody for cell culture, ELISA & in-vivo assay
Go to SERPINA3/SERPINA3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0467-Ab-1/ GM-Tg-hg-SE0467-Ab-2 | Anti-Human SERPINA3 monoclonal antibody | Human |
| GM-Tg-rg-SE0467-Ab-1/ GM-Tg-rg-SE0467-Ab-2 | Anti-Rat SERPINA3 monoclonal antibody | Rat |
| GM-Tg-mg-SE0467-Ab-1/ GM-Tg-mg-SE0467-Ab-2 | Anti-Mouse SERPINA3 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0467-Ab-1/ GM-Tg-cynog-SE0467-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SERPINA3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0467-Ab-1/ GM-Tg-felg-SE0467-Ab-2 | Anti-Feline SERPINA3 monoclonal antibody | Feline |
| GM-Tg-cang-SE0467-Ab-1/ GM-Tg-cang-SE0467-Ab-2 | Anti-Canine SERPINA3 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0467-Ab-1/ GM-Tg-bovg-SE0467-Ab-2 | Anti-Bovine SERPINA3 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0467-Ab-1/ GM-Tg-equg-SE0467-Ab-2 | Anti-Equine SERPINA3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0467-Ab-1/ GM-Tg-hg-SE0467-Ab-2; GM-Tg-rg-SE0467-Ab-1/ GM-Tg-rg-SE0467-Ab-2; GM-Tg-mg-SE0467-Ab-1/ GM-Tg-mg-SE0467-Ab-2; GM-Tg-cynog-SE0467-Ab-1/ GM-Tg-cynog-SE0467-Ab-2; GM-Tg-felg-SE0467-Ab-1/ GM-Tg-felg-SE0467-Ab-2; GM-Tg-cang-SE0467-Ab-1/ GM-Tg-cang-SE0467-Ab-2; GM-Tg-bovg-SE0467-Ab-1/ GM-Tg-bovg-SE0467-Ab-2; GM-Tg-equg-SE0467-Ab-1/ GM-Tg-equg-SE0467-Ab-2 |
| Products Name | Anti-SERPINA3 monoclonal antibody |
| Format | mab |
| Target Name | SERPINA3 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SERPINA3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0467-Ag-1 | Recombinant multi-species AACT/ SERPINA3/ ACT protein |
| ORF Viral Vector | vGMLP002808 | human SERPINA3 Lentivirus particle |
| ORF Viral Vector | pGMLP002808 | human SERPINA3 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm003790 | mouse Serpina3k Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003790 | mouse Serpina3k Lentivirus particle |
Target information
| Target ID | GM-SE0467 |
| Target Name | SERPINA3 |
| Gene ID | 12,574106,480425,101089197,100053600 |
| Gene Symbol and Synonyms | AACT,ACT,GIG24,GIG25,SERPINA3 |
| Uniprot Accession | P01011 |
| Uniprot Entry Name | AACT_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | Diabetes type-2, Diabetic Nephropathy, Kidney transplant rejection, Non-small cell lung carcinoma, Acute appendicitis |
| Gene Ensembl | ENSG00000196136 |
| Target Classification | N/A |
The target: SERPINA3, gene name: SERPINA3, also named as AACT, ACT, GIG24, GIG25. The protein encoded by this gene is a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. This gene is one in a cluster of serpin genes located on the q arm of chromosome 14. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. [provided by RefSeq, Jun 2020].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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