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Anti-APOC1/ Apo-CI/ ApoC-I functional antibody
Anti-APOC1/ Apo-CI/ ApoC-I functional antibody for cell culture, ELISA & in-vivo assay
Go to APOC1/APOC1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0672-Ab-1/ GM-Tg-hg-SE0672-Ab-2 | Anti-Human APOC1 monoclonal antibody | Human |
| GM-Tg-rg-SE0672-Ab-1/ GM-Tg-rg-SE0672-Ab-2 | Anti-Rat APOC1 monoclonal antibody | Rat |
| GM-Tg-mg-SE0672-Ab-1/ GM-Tg-mg-SE0672-Ab-2 | Anti-Mouse APOC1 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0672-Ab-1/ GM-Tg-cynog-SE0672-Ab-2 | Anti-Cynomolgus/ Rhesus macaque APOC1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0672-Ab-1/ GM-Tg-felg-SE0672-Ab-2 | Anti-Feline APOC1 monoclonal antibody | Feline |
| GM-Tg-cang-SE0672-Ab-1/ GM-Tg-cang-SE0672-Ab-2 | Anti-Canine APOC1 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0672-Ab-1/ GM-Tg-bovg-SE0672-Ab-2 | Anti-Bovine APOC1 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0672-Ab-1/ GM-Tg-equg-SE0672-Ab-2 | Anti-Equine APOC1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0672-Ab-1/ GM-Tg-hg-SE0672-Ab-2; GM-Tg-rg-SE0672-Ab-1/ GM-Tg-rg-SE0672-Ab-2; GM-Tg-mg-SE0672-Ab-1/ GM-Tg-mg-SE0672-Ab-2; GM-Tg-cynog-SE0672-Ab-1/ GM-Tg-cynog-SE0672-Ab-2; GM-Tg-felg-SE0672-Ab-1/ GM-Tg-felg-SE0672-Ab-2; GM-Tg-cang-SE0672-Ab-1/ GM-Tg-cang-SE0672-Ab-2; GM-Tg-bovg-SE0672-Ab-1/ GM-Tg-bovg-SE0672-Ab-2; GM-Tg-equg-SE0672-Ab-1/ GM-Tg-equg-SE0672-Ab-2 |
| Products Name | Anti-APOC1 monoclonal antibody |
| Format | mab |
| Target Name | APOC1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-APOC1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0672-Ag-1 | Recombinant multi-species APOC1/ Apo-CI/ ApoC-I protein |
| ORF Viral Vector | vGMLP000390 | human APOC1 Lentivirus particle |
| ORF Viral Vector | pGMLP000390 | human APOC1 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm000021 | mouse Apoc1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000021 | mouse Apoc1 Lentivirus particle |
Target information
| Target ID | GM-SE0672 |
| Target Name | APOC1 |
| Gene ID | 341,11812,25292,106994799,476437,101086520,102147873 |
| Gene Symbol and Synonyms | ALPCI,Apo-CI,apo-CIB,ApoC-I,apoC-IB,APOC1,APOC1B,LRRG04 |
| Uniprot Accession | P02654,P19939,H9FNA4,P56595,P0DM82 |
| Uniprot Entry Name | APOC1_HUMAN,APO1B_MACMU,APOC1_RAT,APOC1_FELCA,APOC1_CANLF |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | gastric cancer |
| Gene Ensembl | ENSG00000130208 |
| Target Classification | N/A |
The target: APOC1, gene name: APOC1, also named as Apo-CI, ApoC-I, apo-CIB, apoC-IB. This gene encodes a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. The encoded protein plays a central role in high density lipoprotein (HDL) and very low density lipoprotein (VLDL) metabolism. This protein has also been shown to inhibit cholesteryl ester transfer protein in plasma. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Sep 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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