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Anti-ARTN/ ART/ ENOVIN functional antibody
Anti-ARTN/ ART/ ENOVIN functional antibody for cell culture, ELISA & in-vivo assay
Go to ARTN/ARTN products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0680-Ab-1/ GM-Tg-hg-SE0680-Ab-2 | Anti-Human ARTN monoclonal antibody | Human |
| GM-Tg-rg-SE0680-Ab-1/ GM-Tg-rg-SE0680-Ab-2 | Anti-Rat ARTN monoclonal antibody | Rat |
| GM-Tg-mg-SE0680-Ab-1/ GM-Tg-mg-SE0680-Ab-2 | Anti-Mouse ARTN monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0680-Ab-1/ GM-Tg-cynog-SE0680-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ARTN monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0680-Ab-1/ GM-Tg-felg-SE0680-Ab-2 | Anti-Feline ARTN monoclonal antibody | Feline |
| GM-Tg-cang-SE0680-Ab-1/ GM-Tg-cang-SE0680-Ab-2 | Anti-Canine ARTN monoclonal antibody | Canine |
| GM-Tg-bovg-SE0680-Ab-1/ GM-Tg-bovg-SE0680-Ab-2 | Anti-Bovine ARTN monoclonal antibody | Bovine |
| GM-Tg-equg-SE0680-Ab-1/ GM-Tg-equg-SE0680-Ab-2 | Anti-Equine ARTN monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0680-Ab-1/ GM-Tg-hg-SE0680-Ab-2; GM-Tg-rg-SE0680-Ab-1/ GM-Tg-rg-SE0680-Ab-2; GM-Tg-mg-SE0680-Ab-1/ GM-Tg-mg-SE0680-Ab-2; GM-Tg-cynog-SE0680-Ab-1/ GM-Tg-cynog-SE0680-Ab-2; GM-Tg-felg-SE0680-Ab-1/ GM-Tg-felg-SE0680-Ab-2; GM-Tg-cang-SE0680-Ab-1/ GM-Tg-cang-SE0680-Ab-2; GM-Tg-bovg-SE0680-Ab-1/ GM-Tg-bovg-SE0680-Ab-2; GM-Tg-equg-SE0680-Ab-1/ GM-Tg-equg-SE0680-Ab-2 |
| Products Name | Anti-ARTN monoclonal antibody |
| Format | mab |
| Target Name | ARTN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ARTN benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0680-Ag-1 | Recombinant multi-species ARTN/ ART/ ENOVIN protein |
| Cytokine | GM-Tg-g-SE0680-Ag-1 | artemin (ARTN) protein |
| ORF Viral Vector | vGMLP004758 | human Artn Lentivirus particle |
| ORF Viral Vector | pGMLP004758 | human Artn Lentivirus plasmid |
| ORF Viral Vector | pGMLPm004545 | mouse Artn Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004545 | mouse Artn Lentivirus particle |
Target information
| Target ID | GM-SE0680 |
| Target Name | ARTN |
| Gene ID | 9048,11876,362572,701641,119868041,111561723,530812,106782773 |
| Gene Symbol and Synonyms | ART,ARTN,ENOVIN,EVN,NBN,neublastin |
| Uniprot Accession | Q5T4W7,Q6AYE8 |
| Uniprot Entry Name | ARTN_HUMAN,ARTN_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000117407 |
| Target Classification | N/A |
The target: ARTN, gene name: ARTN, also named as ART, ENOVIN, EVN, NBN. This gene encodes a secreted ligand of the glial cell line-derived neurotrophic factor (GDNF) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein signals through the RET receptor and GFR alpha 3 coreceptor, and supports the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. This protein has also been shown to promote tumor growth, metastasis, and drug resistance in mammary carcinoma. [provided by RefSeq, Aug 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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