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Anti-CCL18/ AMAC-1/ AMAC1 functional antibody
Anti-CCL18/ AMAC-1/ AMAC1 functional antibody for cell culture, ELISA & in-vivo assay
Go to CCL18/CCL18 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0743-Ab-1/ GM-Tg-hg-SE0743-Ab-2 | Anti-Human CCL18 monoclonal antibody | Human |
| GM-Tg-rg-SE0743-Ab-1/ GM-Tg-rg-SE0743-Ab-2 | Anti-Rat CCL18 monoclonal antibody | Rat |
| GM-Tg-mg-SE0743-Ab-1/ GM-Tg-mg-SE0743-Ab-2 | Anti-Mouse CCL18 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0743-Ab-1/ GM-Tg-cynog-SE0743-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CCL18 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0743-Ab-1/ GM-Tg-felg-SE0743-Ab-2 | Anti-Feline CCL18 monoclonal antibody | Feline |
| GM-Tg-cang-SE0743-Ab-1/ GM-Tg-cang-SE0743-Ab-2 | Anti-Canine CCL18 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0743-Ab-1/ GM-Tg-bovg-SE0743-Ab-2 | Anti-Bovine CCL18 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0743-Ab-1/ GM-Tg-equg-SE0743-Ab-2 | Anti-Equine CCL18 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0743-Ab-1/ GM-Tg-hg-SE0743-Ab-2; GM-Tg-rg-SE0743-Ab-1/ GM-Tg-rg-SE0743-Ab-2; GM-Tg-mg-SE0743-Ab-1/ GM-Tg-mg-SE0743-Ab-2; GM-Tg-cynog-SE0743-Ab-1/ GM-Tg-cynog-SE0743-Ab-2; GM-Tg-felg-SE0743-Ab-1/ GM-Tg-felg-SE0743-Ab-2; GM-Tg-cang-SE0743-Ab-1/ GM-Tg-cang-SE0743-Ab-2; GM-Tg-bovg-SE0743-Ab-1/ GM-Tg-bovg-SE0743-Ab-2; GM-Tg-equg-SE0743-Ab-1/ GM-Tg-equg-SE0743-Ab-2 |
| Products Name | Anti-CCL18 monoclonal antibody |
| Format | mab |
| Target Name | CCL18 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CCL18 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0743-Ag-1 | Recombinant multi-species CCL18/ AMAC-1/ AMAC1 protein |
| Cytokine | GM-Tg-g-SE0743-Ag-1 | chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) (CCL18) protein |
| ORF Viral Vector | vGMLP004613 | human CCL18 Lentivirus particle |
| ORF Viral Vector | pGMLP004613 | human CCL18 Lentivirus plasmid |
Target information
| Target ID | GM-SE0743 |
| Target Name | CCL18 |
| Gene ID | 6362,574181 |
| Gene Symbol and Synonyms | AMAC-1,AMAC1,CCL18,CKb7,DC-CK1,DCCK1,MIP-4,PARC,SCYA18 |
| Uniprot Accession | P55774,Q8HYP8 |
| Uniprot Entry Name | CCL18_HUMAN,CCL18_MACMU |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Cytokine Target |
| Disease | Prostate Cancer, Malignant neoplasm of bladder, Overactive bladder |
| Gene Ensembl | ENSG00000275385 |
| Target Classification | N/A |
The target: CCL18, gene name: CCL18, also named as AMAC-1, AMAC1, CKb7, DC-CK1, DCCK1, MIP-4, PARC, SCYA18. This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in both humoral and cell-mediated immunity responses. [provided by RefSeq, Sep 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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