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Anti-CEL3A/ CELA3A/ ELA3 functional antibody
Anti-CEL3A/ CELA3A/ ELA3 functional antibody for cell culture, ELISA & in-vivo assay
Go to CELA3A/CELA3A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0757-Ab-1/ GM-Tg-hg-SE0757-Ab-2 | Anti-Human CELA3A monoclonal antibody | Human |
| GM-Tg-rg-SE0757-Ab-1/ GM-Tg-rg-SE0757-Ab-2 | Anti-Rat CELA3A monoclonal antibody | Rat |
| GM-Tg-mg-SE0757-Ab-1/ GM-Tg-mg-SE0757-Ab-2 | Anti-Mouse CELA3A monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0757-Ab-1/ GM-Tg-cynog-SE0757-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CELA3A monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0757-Ab-1/ GM-Tg-felg-SE0757-Ab-2 | Anti-Feline CELA3A monoclonal antibody | Feline |
| GM-Tg-cang-SE0757-Ab-1/ GM-Tg-cang-SE0757-Ab-2 | Anti-Canine CELA3A monoclonal antibody | Canine |
| GM-Tg-bovg-SE0757-Ab-1/ GM-Tg-bovg-SE0757-Ab-2 | Anti-Bovine CELA3A monoclonal antibody | Bovine |
| GM-Tg-equg-SE0757-Ab-1/ GM-Tg-equg-SE0757-Ab-2 | Anti-Equine CELA3A monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0757-Ab-1/ GM-Tg-hg-SE0757-Ab-2; GM-Tg-rg-SE0757-Ab-1/ GM-Tg-rg-SE0757-Ab-2; GM-Tg-mg-SE0757-Ab-1/ GM-Tg-mg-SE0757-Ab-2; GM-Tg-cynog-SE0757-Ab-1/ GM-Tg-cynog-SE0757-Ab-2; GM-Tg-felg-SE0757-Ab-1/ GM-Tg-felg-SE0757-Ab-2; GM-Tg-cang-SE0757-Ab-1/ GM-Tg-cang-SE0757-Ab-2; GM-Tg-bovg-SE0757-Ab-1/ GM-Tg-bovg-SE0757-Ab-2; GM-Tg-equg-SE0757-Ab-1/ GM-Tg-equg-SE0757-Ab-2 |
| Products Name | Anti-CELA3A monoclonal antibody |
| Format | mab |
| Target Name | CELA3A |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CELA3A benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0757-Ag-1 | Recombinant multi-species CEL3A/ CELA3A/ ELA3 protein |
| ORF Viral Vector | vGMLP000753 | human ELA3A Lentivirus particle |
| ORF Viral Vector | pGMLP000753 | human ELA3A Lentivirus plasmid |
Target information
| Target ID | GM-SE0757 |
| Target Name | CELA3A |
| Gene ID | 10136 |
| Gene Symbol and Synonyms | CELA3A,ELA3,ELA3A |
| Uniprot Accession | P09093 |
| Uniprot Entry Name | CEL3A_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000142789 |
| Target Classification | N/A |
The target: CELA3A, gene name: CELA3A, also named as ELA3, ELA3A. Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3A has little elastolytic activity. Like most of the human elastases, elastase 3A is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3A preferentially cleaves proteins after alanine residues. Elastase 3A may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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