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Anti-CRDL2/ CHRDL2/ BNF1 functional antibody
Anti-CRDL2/ CHRDL2/ BNF1 functional antibody for cell culture, ELISA & in-vivo assay
Go to CHRDL2/CHRDL2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0778-Ab-1/ GM-Tg-hg-SE0778-Ab-2 | Anti-Human CHRDL2 monoclonal antibody | Human |
| GM-Tg-rg-SE0778-Ab-1/ GM-Tg-rg-SE0778-Ab-2 | Anti-Rat CHRDL2 monoclonal antibody | Rat |
| GM-Tg-mg-SE0778-Ab-1/ GM-Tg-mg-SE0778-Ab-2 | Anti-Mouse CHRDL2 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0778-Ab-1/ GM-Tg-cynog-SE0778-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CHRDL2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0778-Ab-1/ GM-Tg-felg-SE0778-Ab-2 | Anti-Feline CHRDL2 monoclonal antibody | Feline |
| GM-Tg-cang-SE0778-Ab-1/ GM-Tg-cang-SE0778-Ab-2 | Anti-Canine CHRDL2 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0778-Ab-1/ GM-Tg-bovg-SE0778-Ab-2 | Anti-Bovine CHRDL2 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0778-Ab-1/ GM-Tg-equg-SE0778-Ab-2 | Anti-Equine CHRDL2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0778-Ab-1/ GM-Tg-hg-SE0778-Ab-2; GM-Tg-rg-SE0778-Ab-1/ GM-Tg-rg-SE0778-Ab-2; GM-Tg-mg-SE0778-Ab-1/ GM-Tg-mg-SE0778-Ab-2; GM-Tg-cynog-SE0778-Ab-1/ GM-Tg-cynog-SE0778-Ab-2; GM-Tg-felg-SE0778-Ab-1/ GM-Tg-felg-SE0778-Ab-2; GM-Tg-cang-SE0778-Ab-1/ GM-Tg-cang-SE0778-Ab-2; GM-Tg-bovg-SE0778-Ab-1/ GM-Tg-bovg-SE0778-Ab-2; GM-Tg-equg-SE0778-Ab-1/ GM-Tg-equg-SE0778-Ab-2 |
| Products Name | Anti-CHRDL2 monoclonal antibody |
| Format | mab |
| Target Name | CHRDL2 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CHRDL2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0778-Ag-1 | Recombinant multi-species CRDL2/ CHRDL2/ BNF1 protein |
Target information
| Target ID | GM-SE0778 |
| Target Name | CHRDL2 |
| Gene ID | 25884,69121,308854,693657,609312,101093460,533631,100065017 |
| Gene Symbol and Synonyms | 1810022C01Rik,BNF1,CHL2,CHRDL2 |
| Uniprot Accession | Q6WN34 |
| Uniprot Entry Name | CRDL2_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000054938 |
| Target Classification | N/A |
The target: CHRDL2, gene name: CHRDL2, also named as BNF1, CHL2. This gene encodes a member of the chordin family of proteins. Chordin family members are secreted proteins that share a cysteine-rich pro-collagen repeat domain and associate with members of the transforming growth factor beta superfamily. In vitro assays demonstrate a direct interaction between the encoded protein and human activin A. This gene is expressed in many tissues including osteoblasts, where it is differentially expressed during differentiation. In addition, its expression is upregulated in human osteoarthritic joint cartilage, suggesting a role in adult cartilage regeneration. [provided by RefSeq, Jan 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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