Anti-CRIS1/ CRISP1/ AEGL1 functional antibody

Anti-CRIS1/ CRISP1/ AEGL1 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to CRISP1/CRISP1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE0820-Ab-1/ GM-Tg-hg-SE0820-Ab-2Anti-Human CRISP1 monoclonal antibodyHuman
GM-Tg-rg-SE0820-Ab-1/ GM-Tg-rg-SE0820-Ab-2Anti-Rat CRISP1 monoclonal antibodyRat
GM-Tg-mg-SE0820-Ab-1/ GM-Tg-mg-SE0820-Ab-2Anti-Mouse CRISP1 monoclonal antibodyMouse
GM-Tg-cynog-SE0820-Ab-1/ GM-Tg-cynog-SE0820-Ab-2Anti-Cynomolgus/ Rhesus macaque CRISP1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE0820-Ab-1/ GM-Tg-felg-SE0820-Ab-2Anti-Feline CRISP1 monoclonal antibodyFeline
GM-Tg-cang-SE0820-Ab-1/ GM-Tg-cang-SE0820-Ab-2Anti-Canine CRISP1 monoclonal antibodyCanine
GM-Tg-bovg-SE0820-Ab-1/ GM-Tg-bovg-SE0820-Ab-2Anti-Bovine CRISP1 monoclonal antibodyBovine
GM-Tg-equg-SE0820-Ab-1/ GM-Tg-equg-SE0820-Ab-2Anti-Equine CRISP1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE0820-Ab-1/ GM-Tg-hg-SE0820-Ab-2; GM-Tg-rg-SE0820-Ab-1/ GM-Tg-rg-SE0820-Ab-2;
GM-Tg-mg-SE0820-Ab-1/ GM-Tg-mg-SE0820-Ab-2; GM-Tg-cynog-SE0820-Ab-1/ GM-Tg-cynog-SE0820-Ab-2;
GM-Tg-felg-SE0820-Ab-1/ GM-Tg-felg-SE0820-Ab-2; GM-Tg-cang-SE0820-Ab-1/ GM-Tg-cang-SE0820-Ab-2;
GM-Tg-bovg-SE0820-Ab-1/ GM-Tg-bovg-SE0820-Ab-2; GM-Tg-equg-SE0820-Ab-1/ GM-Tg-equg-SE0820-Ab-2
Products NameAnti-CRISP1 monoclonal antibody
Formatmab
Target NameCRISP1
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CRISP1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE0820-Ag-1Recombinant multi-species CRIS1/ CRISP1/ AEGL1 protein
    ORF Viral VectorpGMLP004782human CRISP1 Lentivirus plasmid
    ORF Viral VectorvGMLP004782human CRISP1 Lentivirus particle
    ORF Viral VectorpGMLPm001055mouse Crisp1 Lentivirus plasmid
    ORF Viral VectorvGMLPm001055mouse Crisp1 Lentivirus particle


    Target information

    Target IDGM-SE0820
    Target NameCRISP1
    Gene ID167,11571,654517,574111,100855553,101082060,616774,100033953
    Gene Symbol and SynonymsAEG,Aeg1,AEGL1,ARP,CRISP-1,CRISP1,Crisp4,HEL-S-57,HSCRISP1D,HSCRISP1G,HUMARP,SCP 1
    Uniprot AccessionP54107,Q9XSD3
    Uniprot Entry NameCRIS1_HUMAN,CRIS1_MACMU
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000124812
    Target ClassificationN/A

    The target: CRISP1, gene name: CRISP1, also named as AEGL1, ARP, CRISP-1, HEL-S-57, HSCRISP1D, HSCRISP1G, HUMARP. Fertilization consists of a sequence of specific cell-cell interactions culminating in the fusion of the sperm and egg plasma membranes. Recognition, binding, and fusion occur through the interaction of complementary molecules that are localized to specific domains of the sperm and egg plasma membranes. In the sperm, the postacrosomal region or equatorial segment is involved in sperm-egg plasma membrane fusion. The protein encoded by this gene is a member of the cysteine-rich secretory protein (CRISP) family. It is expressed in the epididymis, is secreted into the epididymal lumen, and binds to the postacrosomal region of the sperm head, where it plays a role in sperm-egg fusion. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.