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Anti-CSHL/ CSHL1/ CS-5 functional antibody
Anti-CSHL/ CSHL1/ CS-5 functional antibody for cell culture, ELISA & in-vivo assay
Go to CSHL1/CSHL1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0828-Ab-1/ GM-Tg-hg-SE0828-Ab-2 | Anti-Human CSHL1 monoclonal antibody | Human |
| GM-Tg-rg-SE0828-Ab-1/ GM-Tg-rg-SE0828-Ab-2 | Anti-Rat CSHL1 monoclonal antibody | Rat |
| GM-Tg-mg-SE0828-Ab-1/ GM-Tg-mg-SE0828-Ab-2 | Anti-Mouse CSHL1 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0828-Ab-1/ GM-Tg-cynog-SE0828-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CSHL1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0828-Ab-1/ GM-Tg-felg-SE0828-Ab-2 | Anti-Feline CSHL1 monoclonal antibody | Feline |
| GM-Tg-cang-SE0828-Ab-1/ GM-Tg-cang-SE0828-Ab-2 | Anti-Canine CSHL1 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0828-Ab-1/ GM-Tg-bovg-SE0828-Ab-2 | Anti-Bovine CSHL1 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0828-Ab-1/ GM-Tg-equg-SE0828-Ab-2 | Anti-Equine CSHL1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0828-Ab-1/ GM-Tg-hg-SE0828-Ab-2; GM-Tg-rg-SE0828-Ab-1/ GM-Tg-rg-SE0828-Ab-2; GM-Tg-mg-SE0828-Ab-1/ GM-Tg-mg-SE0828-Ab-2; GM-Tg-cynog-SE0828-Ab-1/ GM-Tg-cynog-SE0828-Ab-2; GM-Tg-felg-SE0828-Ab-1/ GM-Tg-felg-SE0828-Ab-2; GM-Tg-cang-SE0828-Ab-1/ GM-Tg-cang-SE0828-Ab-2; GM-Tg-bovg-SE0828-Ab-1/ GM-Tg-bovg-SE0828-Ab-2; GM-Tg-equg-SE0828-Ab-1/ GM-Tg-equg-SE0828-Ab-2 |
| Products Name | Anti-CSHL1 monoclonal antibody |
| Format | mab |
| Target Name | CSHL1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CSHL1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0828-Ag-1 | Recombinant multi-species CSHL/ CSHL1/ CS-5 protein |
| ORF Viral Vector | pGMLP004813 | human CSHL1 Lentivirus plasmid |
| ORF Viral Vector | vGMLP004813 | human CSHL1 Lentivirus particle |
| ORF Viral Vector | pGMLPm003830 | mouse Gh Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003830 | mouse Gh Lentivirus particle |
Target information
| Target ID | GM-SE0828 |
| Target Name | CSHL1 |
| Gene ID | 1444 |
| Gene Symbol and Synonyms | CS-5,CSHL1,CSHP1,CSL,GHB4,hCS-L |
| Uniprot Accession | Q14406 |
| Uniprot Entry Name | CSHL_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000204414 |
| Target Classification | N/A |
The target: CSHL1, gene name: CSHL1, also named as CS-5, CSHP1, CSL, GHB4, hCS-L. The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. This particular family member is expressed in placental villi, although it was originally thought to be a pseudogene. In fact, alternative splicing suggests that the majority of the transcripts would be unable to express a secreted protein. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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