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Anti-DEF4/ DEFA4/ HNP-4 functional antibody
Anti-DEF4/ DEFA4/ HNP-4 functional antibody for cell culture, ELISA & in-vivo assay
Go to DEFA4/DEFA4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0852-Ab-1/ GM-Tg-hg-SE0852-Ab-2 | Anti-Human DEFA4 monoclonal antibody | Human |
| GM-Tg-rg-SE0852-Ab-1/ GM-Tg-rg-SE0852-Ab-2 | Anti-Rat DEFA4 monoclonal antibody | Rat |
| GM-Tg-mg-SE0852-Ab-1/ GM-Tg-mg-SE0852-Ab-2 | Anti-Mouse DEFA4 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0852-Ab-1/ GM-Tg-cynog-SE0852-Ab-2 | Anti-Cynomolgus/ Rhesus macaque DEFA4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0852-Ab-1/ GM-Tg-felg-SE0852-Ab-2 | Anti-Feline DEFA4 monoclonal antibody | Feline |
| GM-Tg-cang-SE0852-Ab-1/ GM-Tg-cang-SE0852-Ab-2 | Anti-Canine DEFA4 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0852-Ab-1/ GM-Tg-bovg-SE0852-Ab-2 | Anti-Bovine DEFA4 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0852-Ab-1/ GM-Tg-equg-SE0852-Ab-2 | Anti-Equine DEFA4 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0852-Ab-1/ GM-Tg-hg-SE0852-Ab-2; GM-Tg-rg-SE0852-Ab-1/ GM-Tg-rg-SE0852-Ab-2; GM-Tg-mg-SE0852-Ab-1/ GM-Tg-mg-SE0852-Ab-2; GM-Tg-cynog-SE0852-Ab-1/ GM-Tg-cynog-SE0852-Ab-2; GM-Tg-felg-SE0852-Ab-1/ GM-Tg-felg-SE0852-Ab-2; GM-Tg-cang-SE0852-Ab-1/ GM-Tg-cang-SE0852-Ab-2; GM-Tg-bovg-SE0852-Ab-1/ GM-Tg-bovg-SE0852-Ab-2; GM-Tg-equg-SE0852-Ab-1/ GM-Tg-equg-SE0852-Ab-2 |
| Products Name | Anti-DEFA4 monoclonal antibody |
| Format | mab |
| Target Name | DEFA4 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-DEFA4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0852-Ag-1 | Recombinant multi-species DEF4/ DEFA4/ HNP-4 protein |
Target information
| Target ID | GM-SE0852 |
| Target Name | DEFA4 |
| Gene ID | 1669 |
| Gene Symbol and Synonyms | DEF4,DEFA4,HNP-4,HP-4,HP4 |
| Uniprot Accession | P12838 |
| Uniprot Entry Name | DEF4_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000164821 |
| Target Classification | N/A |
The target: DEFA4, gene name: DEFA4, also named as DEF4, HNP-4, HP-4, HP4. Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes are clustered on chromosome 8. This gene differs from other genes of this family by an extra 83-base segment that is apparently the result of a recent duplication within the coding region. The protein encoded by this gene, defensin, alpha 4, is found in the neutrophils; it exhibits corticostatic activity and inhibits corticotropin stimulated corticosterone production. [provided by RefSeq, Oct 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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