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Anti-DEFB1/ BD1/ DEFB-101 functional antibody
Anti-DEFB1/ BD1/ DEFB-101 functional antibody for cell culture, ELISA & in-vivo assay
Go to DEFB1/DEFB1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0855-Ab-1/ GM-Tg-hg-SE0855-Ab-2 | Anti-Human DEFB1 monoclonal antibody | Human |
| GM-Tg-rg-SE0855-Ab-1/ GM-Tg-rg-SE0855-Ab-2 | Anti-Rat DEFB1 monoclonal antibody | Rat |
| GM-Tg-mg-SE0855-Ab-1/ GM-Tg-mg-SE0855-Ab-2 | Anti-Mouse DEFB1 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0855-Ab-1/ GM-Tg-cynog-SE0855-Ab-2 | Anti-Cynomolgus/ Rhesus macaque DEFB1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0855-Ab-1/ GM-Tg-felg-SE0855-Ab-2 | Anti-Feline DEFB1 monoclonal antibody | Feline |
| GM-Tg-cang-SE0855-Ab-1/ GM-Tg-cang-SE0855-Ab-2 | Anti-Canine DEFB1 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0855-Ab-1/ GM-Tg-bovg-SE0855-Ab-2 | Anti-Bovine DEFB1 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0855-Ab-1/ GM-Tg-equg-SE0855-Ab-2 | Anti-Equine DEFB1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0855-Ab-1/ GM-Tg-hg-SE0855-Ab-2; GM-Tg-rg-SE0855-Ab-1/ GM-Tg-rg-SE0855-Ab-2; GM-Tg-mg-SE0855-Ab-1/ GM-Tg-mg-SE0855-Ab-2; GM-Tg-cynog-SE0855-Ab-1/ GM-Tg-cynog-SE0855-Ab-2; GM-Tg-felg-SE0855-Ab-1/ GM-Tg-felg-SE0855-Ab-2; GM-Tg-cang-SE0855-Ab-1/ GM-Tg-cang-SE0855-Ab-2; GM-Tg-bovg-SE0855-Ab-1/ GM-Tg-bovg-SE0855-Ab-2; GM-Tg-equg-SE0855-Ab-1/ GM-Tg-equg-SE0855-Ab-2 |
| Products Name | Anti-DEFB1 monoclonal antibody |
| Format | mab |
| Target Name | DEFB1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-DEFB1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0855-Ag-1 | Recombinant multi-species DEFB1/ BD1/ DEFB-101 protein |
| ORF Viral Vector | vGMLP000008 | human DEFB1 Lentivirus particle |
| ORF Viral Vector | pGMLP000008 | human DEFB1 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm000075 | mouse Defb1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000075 | mouse Defb1 Lentivirus particle |
Target information
| Target ID | GM-SE0855 |
| Target Name | DEFB1 |
| Gene ID | 1672,83687,574187,611241,102902220,102150198 |
| Gene Symbol and Synonyms | BD1,CBD1,CDK4,DEFB-1,DEFB1,DEFB101,HBD1,RHBD-1 |
| Uniprot Accession | P60022,O89117,O18794 |
| Uniprot Entry Name | DEFB1_HUMAN,DEFB1_MACMU,DEFB1_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | Ovary Cancer, Contrast - Induced Nephropathy, Contact with and (suspected) exposure to arsenic, Kidney transplant rejection |
| Gene Ensembl | ENSG00000164825 |
| Target Classification | N/A |
The target: DEFB1, gene name: DEFB1, also named as BD1, DEFB-101, HBD1, DEFB1. Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member, defensin, alpha 1 and has been implicated in the pathogenesis of cystic fibrosis. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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