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Anti-DKK4/ DKK-4 functional antibody
Anti-DKK4/ DKK-4 functional antibody for cell culture, ELISA & in-vivo assay
Go to DKK4/DKK4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0888-Ab-1/ GM-Tg-hg-SE0888-Ab-2 | Anti-Human DKK4 monoclonal antibody | Human |
| GM-Tg-rg-SE0888-Ab-1/ GM-Tg-rg-SE0888-Ab-2 | Anti-Rat DKK4 monoclonal antibody | Rat |
| GM-Tg-mg-SE0888-Ab-1/ GM-Tg-mg-SE0888-Ab-2 | Anti-Mouse DKK4 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0888-Ab-1/ GM-Tg-cynog-SE0888-Ab-2 | Anti-Cynomolgus/ Rhesus macaque DKK4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0888-Ab-1/ GM-Tg-felg-SE0888-Ab-2 | Anti-Feline DKK4 monoclonal antibody | Feline |
| GM-Tg-cang-SE0888-Ab-1/ GM-Tg-cang-SE0888-Ab-2 | Anti-Canine DKK4 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0888-Ab-1/ GM-Tg-bovg-SE0888-Ab-2 | Anti-Bovine DKK4 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0888-Ab-1/ GM-Tg-equg-SE0888-Ab-2 | Anti-Equine DKK4 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0888-Ab-1/ GM-Tg-hg-SE0888-Ab-2; GM-Tg-rg-SE0888-Ab-1/ GM-Tg-rg-SE0888-Ab-2; GM-Tg-mg-SE0888-Ab-1/ GM-Tg-mg-SE0888-Ab-2; GM-Tg-cynog-SE0888-Ab-1/ GM-Tg-cynog-SE0888-Ab-2; GM-Tg-felg-SE0888-Ab-1/ GM-Tg-felg-SE0888-Ab-2; GM-Tg-cang-SE0888-Ab-1/ GM-Tg-cang-SE0888-Ab-2; GM-Tg-bovg-SE0888-Ab-1/ GM-Tg-bovg-SE0888-Ab-2; GM-Tg-equg-SE0888-Ab-1/ GM-Tg-equg-SE0888-Ab-2 |
| Products Name | Anti-DKK4 monoclonal antibody |
| Format | mab |
| Target Name | DKK4 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-DKK4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0888-Ag-1 | Recombinant multi-species DKK4/ DKK-4 protein |
| ORF Viral Vector | vGMLP002081 | human DKK4 Lentivirus particle |
| ORF Viral Vector | pGMLP002081 | human DKK4 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm003756 | mouse Dkk4 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003756 | mouse Dkk4 Lentivirus particle |
Target information
| Target ID | GM-SE0888 |
| Target Name | DKK4 |
| Gene ID | 27121,234130,502097,705011,607210,101099547,509338,100054568 |
| Gene Symbol and Synonyms | DKK-4,DKK4,RGD1563172 |
| Uniprot Accession | Q9UBT3 |
| Uniprot Entry Name | DKK4_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | Renal cell carcinoma |
| Gene Ensembl | ENSG00000104371 |
| Target Classification | N/A |
The target: DKK4, gene name: DKK4, also named as DKK-4. This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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