Anti-HIS3/ HTN3/ HIS2 functional antibody

Anti-HIS3/ HTN3/ HIS2 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to HTN3/HTN3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE0971-Ab-1/ GM-Tg-hg-SE0971-Ab-2Anti-Human HTN3 monoclonal antibodyHuman
GM-Tg-rg-SE0971-Ab-1/ GM-Tg-rg-SE0971-Ab-2Anti-Rat HTN3 monoclonal antibodyRat
GM-Tg-mg-SE0971-Ab-1/ GM-Tg-mg-SE0971-Ab-2Anti-Mouse HTN3 monoclonal antibodyMouse
GM-Tg-cynog-SE0971-Ab-1/ GM-Tg-cynog-SE0971-Ab-2Anti-Cynomolgus/ Rhesus macaque HTN3 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE0971-Ab-1/ GM-Tg-felg-SE0971-Ab-2Anti-Feline HTN3 monoclonal antibodyFeline
GM-Tg-cang-SE0971-Ab-1/ GM-Tg-cang-SE0971-Ab-2Anti-Canine HTN3 monoclonal antibodyCanine
GM-Tg-bovg-SE0971-Ab-1/ GM-Tg-bovg-SE0971-Ab-2Anti-Bovine HTN3 monoclonal antibodyBovine
GM-Tg-equg-SE0971-Ab-1/ GM-Tg-equg-SE0971-Ab-2Anti-Equine HTN3 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE0971-Ab-1/ GM-Tg-hg-SE0971-Ab-2; GM-Tg-rg-SE0971-Ab-1/ GM-Tg-rg-SE0971-Ab-2;
GM-Tg-mg-SE0971-Ab-1/ GM-Tg-mg-SE0971-Ab-2; GM-Tg-cynog-SE0971-Ab-1/ GM-Tg-cynog-SE0971-Ab-2;
GM-Tg-felg-SE0971-Ab-1/ GM-Tg-felg-SE0971-Ab-2; GM-Tg-cang-SE0971-Ab-1/ GM-Tg-cang-SE0971-Ab-2;
GM-Tg-bovg-SE0971-Ab-1/ GM-Tg-bovg-SE0971-Ab-2; GM-Tg-equg-SE0971-Ab-1/ GM-Tg-equg-SE0971-Ab-2
Products NameAnti-HTN3 monoclonal antibody
Formatmab
Target NameHTN3
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-HTN3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE0971-Ag-1Recombinant multi-species HIS3/ HTN3/ HIS2 protein
    ORF Viral VectorvGMLP002420human HTN3 Lentivirus particle
    ORF Viral VectorpGMLP002420human HTN3 Lentivirus plasmid


    Target information

    Target IDGM-SE0971
    Target NameHTN3
    Gene ID3347
    Gene Symbol and SynonymsHIS2,HTN2,HTN3,HTN5,PB
    Uniprot AccessionP15516
    Uniprot Entry NameHIS3_HUMAN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000205649
    Target ClassificationN/A

    The target: HTN3, gene name: HTN3, also named as HIS2, HTN2, HTN5. This gene encodes a member of the histatin family of small, histidine-rich, cationic proteins. They function as antimicrobial peptides and are important components of the innate immune system. Histatins are found in saliva and exhibit antibacterial, antifungal activities and function in wound healing. [provided by RefSeq, Sep 2014].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.