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Anti-HYAL1/ HYAL-1/ LUCA1 functional antibody
Anti-HYAL1/ HYAL-1/ LUCA1 functional antibody for cell culture, ELISA & in-vivo assay
Go to HYAL1/HYAL1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0973-Ab-1/ GM-Tg-hg-SE0973-Ab-2 | Anti-Human HYAL1 monoclonal antibody | Human |
| GM-Tg-rg-SE0973-Ab-1/ GM-Tg-rg-SE0973-Ab-2 | Anti-Rat HYAL1 monoclonal antibody | Rat |
| GM-Tg-mg-SE0973-Ab-1/ GM-Tg-mg-SE0973-Ab-2 | Anti-Mouse HYAL1 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0973-Ab-1/ GM-Tg-cynog-SE0973-Ab-2 | Anti-Cynomolgus/ Rhesus macaque HYAL1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0973-Ab-1/ GM-Tg-felg-SE0973-Ab-2 | Anti-Feline HYAL1 monoclonal antibody | Feline |
| GM-Tg-cang-SE0973-Ab-1/ GM-Tg-cang-SE0973-Ab-2 | Anti-Canine HYAL1 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0973-Ab-1/ GM-Tg-bovg-SE0973-Ab-2 | Anti-Bovine HYAL1 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0973-Ab-1/ GM-Tg-equg-SE0973-Ab-2 | Anti-Equine HYAL1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0973-Ab-1/ GM-Tg-hg-SE0973-Ab-2; GM-Tg-rg-SE0973-Ab-1/ GM-Tg-rg-SE0973-Ab-2; GM-Tg-mg-SE0973-Ab-1/ GM-Tg-mg-SE0973-Ab-2; GM-Tg-cynog-SE0973-Ab-1/ GM-Tg-cynog-SE0973-Ab-2; GM-Tg-felg-SE0973-Ab-1/ GM-Tg-felg-SE0973-Ab-2; GM-Tg-cang-SE0973-Ab-1/ GM-Tg-cang-SE0973-Ab-2; GM-Tg-bovg-SE0973-Ab-1/ GM-Tg-bovg-SE0973-Ab-2; GM-Tg-equg-SE0973-Ab-1/ GM-Tg-equg-SE0973-Ab-2 |
| Products Name | Anti-HYAL1 monoclonal antibody |
| Format | mab |
| Target Name | HYAL1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-HYAL1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0973-Ag-1 | Recombinant multi-species HYAL1/ HYAL-1/ LUCA1 protein |
| ORF Viral Vector | vGMLP000113 | human HYAL1 Lentivirus particle |
| ORF Viral Vector | pGMLP000113 | human HYAL1 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm001795 | mouse Hyal1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001795 | mouse Hyal1 Lentivirus particle |
Target information
| Target ID | GM-SE0973 |
| Target Name | HYAL1 |
| Gene ID | 3373,15586,367166,702850,515397 |
| Gene Symbol and Synonyms | Fus2,Hya1,HYAL-1,HYAL1,LUCA1,MPS9,NAT6 |
| Uniprot Accession | Q12794,Q76HN1,Q5E985 |
| Uniprot Entry Name | HYAL1_HUMAN,HYAL1_RAT,HYAL1_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000114378 |
| Target Classification | N/A |
The target: HYAL1, gene name: HYAL1, also named as HYAL-1, LUCA1, MPS9, NAT6. This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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