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Anti-SIAL/ IBSP/ BNSP functional antibody
Anti-SIAL/ IBSP/ BNSP functional antibody for cell culture, ELISA & in-vivo assay
Go to IBSP/IBSP products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0974-Ab-1/ GM-Tg-hg-SE0974-Ab-2 | Anti-Human IBSP monoclonal antibody | Human |
| GM-Tg-rg-SE0974-Ab-1/ GM-Tg-rg-SE0974-Ab-2 | Anti-Rat IBSP monoclonal antibody | Rat |
| GM-Tg-mg-SE0974-Ab-1/ GM-Tg-mg-SE0974-Ab-2 | Anti-Mouse IBSP monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0974-Ab-1/ GM-Tg-cynog-SE0974-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IBSP monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0974-Ab-1/ GM-Tg-felg-SE0974-Ab-2 | Anti-Feline IBSP monoclonal antibody | Feline |
| GM-Tg-cang-SE0974-Ab-1/ GM-Tg-cang-SE0974-Ab-2 | Anti-Canine IBSP monoclonal antibody | Canine |
| GM-Tg-bovg-SE0974-Ab-1/ GM-Tg-bovg-SE0974-Ab-2 | Anti-Bovine IBSP monoclonal antibody | Bovine |
| GM-Tg-equg-SE0974-Ab-1/ GM-Tg-equg-SE0974-Ab-2 | Anti-Equine IBSP monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0974-Ab-1/ GM-Tg-hg-SE0974-Ab-2; GM-Tg-rg-SE0974-Ab-1/ GM-Tg-rg-SE0974-Ab-2; GM-Tg-mg-SE0974-Ab-1/ GM-Tg-mg-SE0974-Ab-2; GM-Tg-cynog-SE0974-Ab-1/ GM-Tg-cynog-SE0974-Ab-2; GM-Tg-felg-SE0974-Ab-1/ GM-Tg-felg-SE0974-Ab-2; GM-Tg-cang-SE0974-Ab-1/ GM-Tg-cang-SE0974-Ab-2; GM-Tg-bovg-SE0974-Ab-1/ GM-Tg-bovg-SE0974-Ab-2; GM-Tg-equg-SE0974-Ab-1/ GM-Tg-equg-SE0974-Ab-2 |
| Products Name | Anti-IBSP monoclonal antibody |
| Format | mab |
| Target Name | IBSP |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IBSP benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0974-Ag-1 | Recombinant multi-species SIAL/ IBSP/ BNSP protein |
| ORF Viral Vector | vGMLP004991 | human IBSP Lentivirus particle |
| ORF Viral Vector | pGMLP004991 | human IBSP Lentivirus plasmid |
| ORF Viral Vector | pGMLPm004614 | mouse Ibsp Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004614 | mouse Ibsp Lentivirus particle |
Target information
| Target ID | GM-SE0974 |
| Target Name | IBSP |
| Gene ID | 3381,15891,24477,701835,609146,101095252,281233,100052979 |
| Gene Symbol and Synonyms | BNSP,BSP,BSP II,BSP-II,Bsp2,BSPII,IBSP,SP-II |
| Uniprot Accession | P21815,P13839,Q28862 |
| Uniprot Entry Name | SIAL_HUMAN,SIAL_RAT,SIAL_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | breast cancer |
| Gene Ensembl | ENSG00000029559 |
| Target Classification | N/A |
The target: IBSP, gene name: IBSP, also named as BNSP, BSP, BSP-II, SP-II. The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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