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Anti-KAZD1/ KAZALD1/ BONO1 functional antibody
Anti-KAZD1/ KAZALD1/ BONO1 functional antibody for cell culture, ELISA & in-vivo assay
Go to KAZALD1/KAZALD1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1044-Ab-1/ GM-Tg-hg-SE1044-Ab-2 | Anti-Human KAZALD1 monoclonal antibody | Human |
| GM-Tg-rg-SE1044-Ab-1/ GM-Tg-rg-SE1044-Ab-2 | Anti-Rat KAZALD1 monoclonal antibody | Rat |
| GM-Tg-mg-SE1044-Ab-1/ GM-Tg-mg-SE1044-Ab-2 | Anti-Mouse KAZALD1 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1044-Ab-1/ GM-Tg-cynog-SE1044-Ab-2 | Anti-Cynomolgus/ Rhesus macaque KAZALD1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1044-Ab-1/ GM-Tg-felg-SE1044-Ab-2 | Anti-Feline KAZALD1 monoclonal antibody | Feline |
| GM-Tg-cang-SE1044-Ab-1/ GM-Tg-cang-SE1044-Ab-2 | Anti-Canine KAZALD1 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1044-Ab-1/ GM-Tg-bovg-SE1044-Ab-2 | Anti-Bovine KAZALD1 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1044-Ab-1/ GM-Tg-equg-SE1044-Ab-2 | Anti-Equine KAZALD1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1044-Ab-1/ GM-Tg-hg-SE1044-Ab-2; GM-Tg-rg-SE1044-Ab-1/ GM-Tg-rg-SE1044-Ab-2; GM-Tg-mg-SE1044-Ab-1/ GM-Tg-mg-SE1044-Ab-2; GM-Tg-cynog-SE1044-Ab-1/ GM-Tg-cynog-SE1044-Ab-2; GM-Tg-felg-SE1044-Ab-1/ GM-Tg-felg-SE1044-Ab-2; GM-Tg-cang-SE1044-Ab-1/ GM-Tg-cang-SE1044-Ab-2; GM-Tg-bovg-SE1044-Ab-1/ GM-Tg-bovg-SE1044-Ab-2; GM-Tg-equg-SE1044-Ab-1/ GM-Tg-equg-SE1044-Ab-2 |
| Products Name | Anti-KAZALD1 monoclonal antibody |
| Format | mab |
| Target Name | KAZALD1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-KAZALD1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1044-Ag-1 | Recombinant multi-species KAZD1/ KAZALD1/ BONO1 protein |
| Cytokine | GM-Tg-g-SE1044-Ag-1 | Kazal-type serine peptidase inhibitor domain 1 (KAZALD1) protein |
Target information
| Target ID | GM-SE1044 |
| Target Name | KAZALD1 |
| Gene ID | 81621,107250,293997,711518,609313,101095134,617445,100060342 |
| Gene Symbol and Synonyms | BONO1,FKSG28,FKSG40,IGFBP-rP10,KAZALD1 |
| Uniprot Accession | Q96I82 |
| Uniprot Entry Name | KAZD1_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000107821 |
| Target Classification | N/A |
The target: KAZALD1, gene name: KAZALD1, also named as BONO1, FKSG28, FKSG40, IGFBP-rP10. This gene encodes a secreted member of the insulin growth factor-binding protein (IGFBP) superfamily. The protein contains an insulin growth factor-binding domain in its N-terminal region, a Kazal-type serine protease inhibitor and follistatin-like domain in its central region, and an immunoglobulin-like domain in its C-terminal region. Studies of the mouse ortholog suggest that this protein may function in bone development and bone regeneration. This gene is hypomethylated and over-expressed in high-grade glioma compared to low-grade glioma, and thus the hypomethylated gene may be associated with cell proliferation and the shorter survival of patients with high-grade glioma. It is also one of numerous genes found to be deleted in a novel 5.54 Mb interstitial deletion, which is associated with multiple congenital anomalies. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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