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Anti-KLK10/ NES1/ PRSSL1 functional antibody
Anti-KLK10/ NES1/ PRSSL1 functional antibody for cell culture, ELISA & in-vivo assay
Go to KLK10/KLK10 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1047-Ab-1/ GM-Tg-hg-SE1047-Ab-2 | Anti-Human KLK10 monoclonal antibody | Human |
| GM-Tg-rg-SE1047-Ab-1/ GM-Tg-rg-SE1047-Ab-2 | Anti-Rat KLK10 monoclonal antibody | Rat |
| GM-Tg-mg-SE1047-Ab-1/ GM-Tg-mg-SE1047-Ab-2 | Anti-Mouse KLK10 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1047-Ab-1/ GM-Tg-cynog-SE1047-Ab-2 | Anti-Cynomolgus/ Rhesus macaque KLK10 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1047-Ab-1/ GM-Tg-felg-SE1047-Ab-2 | Anti-Feline KLK10 monoclonal antibody | Feline |
| GM-Tg-cang-SE1047-Ab-1/ GM-Tg-cang-SE1047-Ab-2 | Anti-Canine KLK10 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1047-Ab-1/ GM-Tg-bovg-SE1047-Ab-2 | Anti-Bovine KLK10 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1047-Ab-1/ GM-Tg-equg-SE1047-Ab-2 | Anti-Equine KLK10 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1047-Ab-1/ GM-Tg-hg-SE1047-Ab-2; GM-Tg-rg-SE1047-Ab-1/ GM-Tg-rg-SE1047-Ab-2; GM-Tg-mg-SE1047-Ab-1/ GM-Tg-mg-SE1047-Ab-2; GM-Tg-cynog-SE1047-Ab-1/ GM-Tg-cynog-SE1047-Ab-2; GM-Tg-felg-SE1047-Ab-1/ GM-Tg-felg-SE1047-Ab-2; GM-Tg-cang-SE1047-Ab-1/ GM-Tg-cang-SE1047-Ab-2; GM-Tg-bovg-SE1047-Ab-1/ GM-Tg-bovg-SE1047-Ab-2; GM-Tg-equg-SE1047-Ab-1/ GM-Tg-equg-SE1047-Ab-2 |
| Products Name | Anti-KLK10 monoclonal antibody |
| Format | mab |
| Target Name | KLK10 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-KLK10 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1047-Ag-1 | Recombinant multi-species KLK10/ NES1/ PRSSL1 protein |
| ORF Viral Vector | pGMLP004037 | human KLK10 Lentivirus plasmid |
| ORF Viral Vector | pGMLP003500 | human KLK10 Lentivirus plasmid |
| ORF Viral Vector | vGMLP004037 | human KLK10 Lentivirus particle |
| ORF Viral Vector | vGMLP003500 | human KLK10 Lentivirus particle |
| ORF Viral Vector | pGMLPm001044 | mouse Klk10 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001044 | mouse Klk10 Lentivirus particle |
Target information
| Target ID | GM-SE1047 |
| Target Name | KLK10 |
| Gene ID | 5655,69540,292850,106994828,484351,101088633,526736,100146904 |
| Gene Symbol and Synonyms | 2300002A13Rik,KLK10,Klnj,NES1,PRSSL1 |
| Uniprot Accession | O43240 |
| Uniprot Entry Name | KLK10_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000129451 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: KLK10, gene name: KLK10, also named as NES1, PRSSL1. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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