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Anti-LCN1/ PMFA/ TLC functional antibody
Anti-LCN1/ PMFA/ TLC functional antibody for cell culture, ELISA & in-vivo assay
Go to LCN1/LCN1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1059-Ab-1/ GM-Tg-hg-SE1059-Ab-2 | Anti-Human LCN1 monoclonal antibody | Human |
| GM-Tg-rg-SE1059-Ab-1/ GM-Tg-rg-SE1059-Ab-2 | Anti-Rat LCN1 monoclonal antibody | Rat |
| GM-Tg-mg-SE1059-Ab-1/ GM-Tg-mg-SE1059-Ab-2 | Anti-Mouse LCN1 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1059-Ab-1/ GM-Tg-cynog-SE1059-Ab-2 | Anti-Cynomolgus/ Rhesus macaque LCN1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1059-Ab-1/ GM-Tg-felg-SE1059-Ab-2 | Anti-Feline LCN1 monoclonal antibody | Feline |
| GM-Tg-cang-SE1059-Ab-1/ GM-Tg-cang-SE1059-Ab-2 | Anti-Canine LCN1 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1059-Ab-1/ GM-Tg-bovg-SE1059-Ab-2 | Anti-Bovine LCN1 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1059-Ab-1/ GM-Tg-equg-SE1059-Ab-2 | Anti-Equine LCN1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1059-Ab-1/ GM-Tg-hg-SE1059-Ab-2; GM-Tg-rg-SE1059-Ab-1/ GM-Tg-rg-SE1059-Ab-2; GM-Tg-mg-SE1059-Ab-1/ GM-Tg-mg-SE1059-Ab-2; GM-Tg-cynog-SE1059-Ab-1/ GM-Tg-cynog-SE1059-Ab-2; GM-Tg-felg-SE1059-Ab-1/ GM-Tg-felg-SE1059-Ab-2; GM-Tg-cang-SE1059-Ab-1/ GM-Tg-cang-SE1059-Ab-2; GM-Tg-bovg-SE1059-Ab-1/ GM-Tg-bovg-SE1059-Ab-2; GM-Tg-equg-SE1059-Ab-1/ GM-Tg-equg-SE1059-Ab-2 |
| Products Name | Anti-LCN1 monoclonal antibody |
| Format | mab |
| Target Name | LCN1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-LCN1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1059-Ag-1 | Recombinant multi-species LCN1/ PMFA/ TLC protein |
| ORF Viral Vector | pGMLP004494 | human LCN1 Lentivirus plasmid |
| ORF Viral Vector | vGMLP004494 | human LCN1 Lentivirus particle |
Target information
| Target ID | GM-SE1059 |
| Target Name | LCN1 |
| Gene ID | 3933,711974,511158 |
| Gene Symbol and Synonyms | LCN1,PMFA,TLC,TP,VEGP |
| Uniprot Accession | P31025 |
| Uniprot Entry Name | LCN1_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000160349 |
| Target Classification | N/A |
The target: LCN1, gene name: LCN1, also named as PMFA, TLC, TP, VEGP. This gene encodes a member of the lipocalin family of small secretory proteins. Lipocalins are extracellular transport proteins that bind to a variety of hydrophobic ligands. The encoded protein is the primary lipid binding protein in tears and is overproduced in response to multiple stimuli including infection and stress. The encoded protein may be a marker for chromosome aneuploidy as well as an autoantigen in Sjogren's syndrome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and two pseudogenes of this gene are also located on the long arm of chromosome 9. [provided by RefSeq, Nov 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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