Anti-PAEP/ GD/ GdA functional antibody

Anti-PAEP/ GD/ GdA functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to PAEP/PAEP products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1166-Ab-1/ GM-Tg-hg-SE1166-Ab-2Anti-Human PAEP monoclonal antibodyHuman
GM-Tg-rg-SE1166-Ab-1/ GM-Tg-rg-SE1166-Ab-2Anti-Rat PAEP monoclonal antibodyRat
GM-Tg-mg-SE1166-Ab-1/ GM-Tg-mg-SE1166-Ab-2Anti-Mouse PAEP monoclonal antibodyMouse
GM-Tg-cynog-SE1166-Ab-1/ GM-Tg-cynog-SE1166-Ab-2Anti-Cynomolgus/ Rhesus macaque PAEP monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1166-Ab-1/ GM-Tg-felg-SE1166-Ab-2Anti-Feline PAEP monoclonal antibodyFeline
GM-Tg-cang-SE1166-Ab-1/ GM-Tg-cang-SE1166-Ab-2Anti-Canine PAEP monoclonal antibodyCanine
GM-Tg-bovg-SE1166-Ab-1/ GM-Tg-bovg-SE1166-Ab-2Anti-Bovine PAEP monoclonal antibodyBovine
GM-Tg-equg-SE1166-Ab-1/ GM-Tg-equg-SE1166-Ab-2Anti-Equine PAEP monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1166-Ab-1/ GM-Tg-hg-SE1166-Ab-2; GM-Tg-rg-SE1166-Ab-1/ GM-Tg-rg-SE1166-Ab-2;
GM-Tg-mg-SE1166-Ab-1/ GM-Tg-mg-SE1166-Ab-2; GM-Tg-cynog-SE1166-Ab-1/ GM-Tg-cynog-SE1166-Ab-2;
GM-Tg-felg-SE1166-Ab-1/ GM-Tg-felg-SE1166-Ab-2; GM-Tg-cang-SE1166-Ab-1/ GM-Tg-cang-SE1166-Ab-2;
GM-Tg-bovg-SE1166-Ab-1/ GM-Tg-bovg-SE1166-Ab-2; GM-Tg-equg-SE1166-Ab-1/ GM-Tg-equg-SE1166-Ab-2
Products NameAnti-PAEP monoclonal antibody
Formatmab
Target NamePAEP
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-PAEP benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1166-Ag-1Recombinant multi-species PAEP/ GD/ GdA protein
    ORF Viral VectorvGMLP002959human PAEP Lentivirus particle
    ORF Viral VectorpGMLP002959human PAEP Lentivirus plasmid


    Target information

    Target IDGM-SE1166
    Target NamePAEP
    Gene ID5047,721853
    Gene Symbol and SynonymsGD,GdA,GdF,GdS,PAEG,PAEP,PEP,PP14,ZIF-1
    Uniprot AccessionP09466
    Uniprot Entry NamePAEP_HUMAN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseCancer
    Gene EnsemblENSG00000122133
    Target ClassificationTumor-associated antigen (TAA)

    The target: PAEP, gene name: PAEP, also named as GD, GdA, GdF, GdS, PAEG, PEP, PP14, ZIF-1. This gene is a member of the kernel lipocalin superfamily whose members share relatively low sequence similarity but have highly conserved exon/intron structure and three-dimensional protein folding. Most lipocalins are clustered on the long arm of chromosome 9. The encoded glycoprotein has been previously referred to as pregnancy-associated endometrial alpha-2-globulin, placental protein 14, and glycodelin, but has been officially named progestagen-associated endometrial protein. Three distinct forms, with identical protein backbones but different glycosylation profiles, are found in amniotic fluid, follicular fluid and seminal plasma of the reproductive system. These glycoproteins have distinct and essential roles in regulating a uterine environment suitable for pregnancy and in the timing and occurrence of the appropriate sequence of events in the fertilization process. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.