- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-PG12B/ PLA2G12B/ FKSG71 functional antibody
Anti-PG12B/ PLA2G12B/ FKSG71 functional antibody for cell culture, ELISA & in-vivo assay
Go to PLA2G12B/PLA2G12B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1191-Ab-1/ GM-Tg-hg-SE1191-Ab-2 | Anti-Human PLA2G12B monoclonal antibody | Human |
| GM-Tg-rg-SE1191-Ab-1/ GM-Tg-rg-SE1191-Ab-2 | Anti-Rat PLA2G12B monoclonal antibody | Rat |
| GM-Tg-mg-SE1191-Ab-1/ GM-Tg-mg-SE1191-Ab-2 | Anti-Mouse PLA2G12B monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1191-Ab-1/ GM-Tg-cynog-SE1191-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PLA2G12B monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1191-Ab-1/ GM-Tg-felg-SE1191-Ab-2 | Anti-Feline PLA2G12B monoclonal antibody | Feline |
| GM-Tg-cang-SE1191-Ab-1/ GM-Tg-cang-SE1191-Ab-2 | Anti-Canine PLA2G12B monoclonal antibody | Canine |
| GM-Tg-bovg-SE1191-Ab-1/ GM-Tg-bovg-SE1191-Ab-2 | Anti-Bovine PLA2G12B monoclonal antibody | Bovine |
| GM-Tg-equg-SE1191-Ab-1/ GM-Tg-equg-SE1191-Ab-2 | Anti-Equine PLA2G12B monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1191-Ab-1/ GM-Tg-hg-SE1191-Ab-2; GM-Tg-rg-SE1191-Ab-1/ GM-Tg-rg-SE1191-Ab-2; GM-Tg-mg-SE1191-Ab-1/ GM-Tg-mg-SE1191-Ab-2; GM-Tg-cynog-SE1191-Ab-1/ GM-Tg-cynog-SE1191-Ab-2; GM-Tg-felg-SE1191-Ab-1/ GM-Tg-felg-SE1191-Ab-2; GM-Tg-cang-SE1191-Ab-1/ GM-Tg-cang-SE1191-Ab-2; GM-Tg-bovg-SE1191-Ab-1/ GM-Tg-bovg-SE1191-Ab-2; GM-Tg-equg-SE1191-Ab-1/ GM-Tg-equg-SE1191-Ab-2 |
| Products Name | Anti-PLA2G12B monoclonal antibody |
| Format | mab |
| Target Name | PLA2G12B |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PLA2G12B benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1191-Ag-1 | Recombinant multi-species PG12B/ PLA2G12B/ FKSG71 protein |
| ORF Viral Vector | vGMLP004714 | human PLA2G12B Lentivirus particle |
| ORF Viral Vector | pGMLP004714 | human PLA2G12B Lentivirus plasmid |
| ORF Viral Vector | pGMLPm004143 | mouse Pla2g12b Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004143 | mouse Pla2g12b Lentivirus particle |
Target information
| Target ID | GM-SE1191 |
| Target Name | PLA2G12B |
| Gene ID | 84647,69836,367415,708031,489045,101083969,100337447,100063726 |
| Gene Symbol and Synonyms | 2010002E04Rik,FKSG71,GXIIB,GXIIIsPLA2,hlb218,PLA2G12B,PLA2G13,sPLA2-GXIIB |
| Uniprot Accession | Q9BX93 |
| Uniprot Entry Name | PG12B_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000138308 |
| Target Classification | N/A |
The target: PLA2G12B, gene name: PLA2G12B, also named as FKSG71, GXIIB, GXIIIsPLA2, PLA2G13, sPLA2-GXIIB. The protein encoded by this gene belongs to the phospholipase A2 (PLA2) group of enzymes, which function in glycolipid hydrolysis with the release of free fatty acids and lysophospholipids. This family member has altered phospholipid-binding properties and is catalytically inactive. The protein is secreted, and together with microsomal triglyceride transfer protein, it functions to regulate HNF4alpha-induced hepatitis C virus infectivity. The expression of this gene is down-regulated in various tumors, suggesting that it may function as a negative regulator of tumor progression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
