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Anti-TRY2/ PRSS2/ TRY8 functional antibody
Anti-TRY2/ PRSS2/ TRY8 functional antibody for cell culture, ELISA & in-vivo assay
Go to PRSS2/PRSS2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1211-Ab-1/ GM-Tg-hg-SE1211-Ab-2 | Anti-Human PRSS2 monoclonal antibody | Human |
| GM-Tg-rg-SE1211-Ab-1/ GM-Tg-rg-SE1211-Ab-2 | Anti-Rat PRSS2 monoclonal antibody | Rat |
| GM-Tg-mg-SE1211-Ab-1/ GM-Tg-mg-SE1211-Ab-2 | Anti-Mouse PRSS2 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1211-Ab-1/ GM-Tg-cynog-SE1211-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PRSS2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1211-Ab-1/ GM-Tg-felg-SE1211-Ab-2 | Anti-Feline PRSS2 monoclonal antibody | Feline |
| GM-Tg-cang-SE1211-Ab-1/ GM-Tg-cang-SE1211-Ab-2 | Anti-Canine PRSS2 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1211-Ab-1/ GM-Tg-bovg-SE1211-Ab-2 | Anti-Bovine PRSS2 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1211-Ab-1/ GM-Tg-equg-SE1211-Ab-2 | Anti-Equine PRSS2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1211-Ab-1/ GM-Tg-hg-SE1211-Ab-2; GM-Tg-rg-SE1211-Ab-1/ GM-Tg-rg-SE1211-Ab-2; GM-Tg-mg-SE1211-Ab-1/ GM-Tg-mg-SE1211-Ab-2; GM-Tg-cynog-SE1211-Ab-1/ GM-Tg-cynog-SE1211-Ab-2; GM-Tg-felg-SE1211-Ab-1/ GM-Tg-felg-SE1211-Ab-2; GM-Tg-cang-SE1211-Ab-1/ GM-Tg-cang-SE1211-Ab-2; GM-Tg-bovg-SE1211-Ab-1/ GM-Tg-bovg-SE1211-Ab-2; GM-Tg-equg-SE1211-Ab-1/ GM-Tg-equg-SE1211-Ab-2 |
| Products Name | Anti-PRSS2 monoclonal antibody |
| Format | mab |
| Target Name | PRSS2 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PRSS2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1211-Ag-1 | Recombinant multi-species TRY2/ PRSS2/ TRY8 protein |
| ORF Viral Vector | pGMLP001201 | human PRSS2 Lentivirus plasmid |
| ORF Viral Vector | vGMLP001201 | human PRSS2 Lentivirus particle |
| ORF Viral Vector | pGMLPm001219 | mouse Prss2 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm003754 | mouse Prss2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001219 | mouse Prss2 Lentivirus particle |
| ORF Viral Vector | vGMLPm003754 | mouse Prss2 Lentivirus particle |
Target information
| Target ID | GM-SE1211 |
| Target Name | PRSS2 |
| Gene ID | 5645,698352,100686744,101085707,282603 |
| Gene Symbol and Synonyms | PRSS2,try10,TRY2,TRY8,TRYP2,TRYP8 |
| Uniprot Accession | P07478,P06872,Q29463 |
| Uniprot Entry Name | TRY2_HUMAN,TRY2_CANLF,TRY2_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | Pancreatitis, Acute pancreatitis |
| Gene Ensembl | ENSG00000275896 |
| Target Classification | N/A |
The target: PRSS2, gene name: PRSS2, also named as TRY2, TRY8, TRYP2. This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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