Anti-1433S/ SFN/ YWHAS functional antibody

Anti-1433S/ SFN/ YWHAS functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to SFN/SFN products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1283-Ab-1/ GM-Tg-hg-SE1283-Ab-2Anti-Human SFN monoclonal antibodyHuman
GM-Tg-rg-SE1283-Ab-1/ GM-Tg-rg-SE1283-Ab-2Anti-Rat SFN monoclonal antibodyRat
GM-Tg-mg-SE1283-Ab-1/ GM-Tg-mg-SE1283-Ab-2Anti-Mouse SFN monoclonal antibodyMouse
GM-Tg-cynog-SE1283-Ab-1/ GM-Tg-cynog-SE1283-Ab-2Anti-Cynomolgus/ Rhesus macaque SFN monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1283-Ab-1/ GM-Tg-felg-SE1283-Ab-2Anti-Feline SFN monoclonal antibodyFeline
GM-Tg-cang-SE1283-Ab-1/ GM-Tg-cang-SE1283-Ab-2Anti-Canine SFN monoclonal antibodyCanine
GM-Tg-bovg-SE1283-Ab-1/ GM-Tg-bovg-SE1283-Ab-2Anti-Bovine SFN monoclonal antibodyBovine
GM-Tg-equg-SE1283-Ab-1/ GM-Tg-equg-SE1283-Ab-2Anti-Equine SFN monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1283-Ab-1/ GM-Tg-hg-SE1283-Ab-2; GM-Tg-rg-SE1283-Ab-1/ GM-Tg-rg-SE1283-Ab-2;
GM-Tg-mg-SE1283-Ab-1/ GM-Tg-mg-SE1283-Ab-2; GM-Tg-cynog-SE1283-Ab-1/ GM-Tg-cynog-SE1283-Ab-2;
GM-Tg-felg-SE1283-Ab-1/ GM-Tg-felg-SE1283-Ab-2; GM-Tg-cang-SE1283-Ab-1/ GM-Tg-cang-SE1283-Ab-2;
GM-Tg-bovg-SE1283-Ab-1/ GM-Tg-bovg-SE1283-Ab-2; GM-Tg-equg-SE1283-Ab-1/ GM-Tg-equg-SE1283-Ab-2
Products NameAnti-SFN monoclonal antibody
Formatmab
Target NameSFN
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-SFN benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1283-Ag-1Recombinant multi-species 1433S/ SFN/ YWHAS protein
    ORF Viral VectorpGMLP002188human SFN Lentivirus plasmid
    ORF Viral VectorvGMLP002188human SFN Lentivirus particle
    ORF Viral VectorpGMLPm001220mouse Sfn Lentivirus plasmid
    ORF Viral VectorvGMLPm001220mouse Sfn Lentivirus particle


    Target information

    Target IDGM-SE1283
    Target NameSFN
    Gene ID2810,55948,313017,715055,487351,101087501,528453,100057082
    Gene Symbol and Synonyms14-3-3,Er,Mme1,SFN,YWHAS
    Uniprot AccessionP31947,Q0VC36
    Uniprot Entry Name1433S_HUMAN,1433S_BOVIN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000175793
    Target ClassificationN/A

    The target: SFN, gene name: SFN, also named as YWHAS. This gene encodes a cell cycle checkpoint protein. The encoded protein binds to translation and initiation factors and functions as a regulator of mitotic translation. In response to DNA damage this protein plays a role in preventing DNA errors during mitosis. [provided by RefSeq, Aug 2017].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.