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Anti-ISK1/ SPINK1/ PCTT functional antibody
Anti-ISK1/ SPINK1/ PCTT functional antibody for cell culture, ELISA & in-vivo assay
Go to SPINK1/SPINK1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1309-Ab-1/ GM-Tg-hg-SE1309-Ab-2 | Anti-Human SPINK1 monoclonal antibody | Human |
| GM-Tg-rg-SE1309-Ab-1/ GM-Tg-rg-SE1309-Ab-2 | Anti-Rat SPINK1 monoclonal antibody | Rat |
| GM-Tg-mg-SE1309-Ab-1/ GM-Tg-mg-SE1309-Ab-2 | Anti-Mouse SPINK1 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1309-Ab-1/ GM-Tg-cynog-SE1309-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SPINK1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1309-Ab-1/ GM-Tg-felg-SE1309-Ab-2 | Anti-Feline SPINK1 monoclonal antibody | Feline |
| GM-Tg-cang-SE1309-Ab-1/ GM-Tg-cang-SE1309-Ab-2 | Anti-Canine SPINK1 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1309-Ab-1/ GM-Tg-bovg-SE1309-Ab-2 | Anti-Bovine SPINK1 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1309-Ab-1/ GM-Tg-equg-SE1309-Ab-2 | Anti-Equine SPINK1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1309-Ab-1/ GM-Tg-hg-SE1309-Ab-2; GM-Tg-rg-SE1309-Ab-1/ GM-Tg-rg-SE1309-Ab-2; GM-Tg-mg-SE1309-Ab-1/ GM-Tg-mg-SE1309-Ab-2; GM-Tg-cynog-SE1309-Ab-1/ GM-Tg-cynog-SE1309-Ab-2; GM-Tg-felg-SE1309-Ab-1/ GM-Tg-felg-SE1309-Ab-2; GM-Tg-cang-SE1309-Ab-1/ GM-Tg-cang-SE1309-Ab-2; GM-Tg-bovg-SE1309-Ab-1/ GM-Tg-bovg-SE1309-Ab-2; GM-Tg-equg-SE1309-Ab-1/ GM-Tg-equg-SE1309-Ab-2 |
| Products Name | Anti-SPINK1 monoclonal antibody |
| Format | mab |
| Target Name | SPINK1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SPINK1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1309-Ag-1 | Recombinant multi-species ISK1/ SPINK1/ PCTT protein |
| ORF Viral Vector | vGMLP002897 | human SPINK1 Lentivirus particle |
| ORF Viral Vector | pGMLP002897 | human SPINK1 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm002202 | mouse Spink1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002202 | mouse Spink1 Lentivirus particle |
Target information
| Target ID | GM-SE1309 |
| Target Name | SPINK1 |
| Gene ID | 6690,20730,708951,608433,101085948,574092,100630883 |
| Gene Symbol and Synonyms | p12,PCTT,PSTI,SPINK1,Spink3,TATI,TCP |
| Uniprot Accession | P00995,P04542,P00996,P81634 |
| Uniprot Entry Name | ISK1_HUMAN,ISK1_CANLF,ISK1_BOVIN,ISK1_HORSE |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | Prostate Cancer |
| Gene Ensembl | ENSG00000164266 |
| Target Classification | N/A |
The target: SPINK1, gene name: SPINK1, also named as PCTT, PSTI, Spink3, TATI, TCP. The protein encoded by this gene is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. It is thought to function in the prevention of trypsin-catalyzed premature activation of zymogens within the pancreas and the pancreatic duct. Mutations in this gene are associated with hereditary pancreatitis and tropical calcific pancreatitis. [provided by RefSeq, Oct 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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