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Anti-TKNK/ TAC3/ HH10 functional antibody
Anti-TKNK/ TAC3/ HH10 functional antibody for cell culture, ELISA & in-vivo assay
Go to TAC3/TAC3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1328-Ab-1/ GM-Tg-hg-SE1328-Ab-2 | Anti-Human TAC3 monoclonal antibody | Human |
| GM-Tg-rg-SE1328-Ab-1/ GM-Tg-rg-SE1328-Ab-2 | Anti-Rat TAC3 monoclonal antibody | Rat |
| GM-Tg-mg-SE1328-Ab-1/ GM-Tg-mg-SE1328-Ab-2 | Anti-Mouse TAC3 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1328-Ab-1/ GM-Tg-cynog-SE1328-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TAC3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1328-Ab-1/ GM-Tg-felg-SE1328-Ab-2 | Anti-Feline TAC3 monoclonal antibody | Feline |
| GM-Tg-cang-SE1328-Ab-1/ GM-Tg-cang-SE1328-Ab-2 | Anti-Canine TAC3 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1328-Ab-1/ GM-Tg-bovg-SE1328-Ab-2 | Anti-Bovine TAC3 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1328-Ab-1/ GM-Tg-equg-SE1328-Ab-2 | Anti-Equine TAC3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1328-Ab-1/ GM-Tg-hg-SE1328-Ab-2; GM-Tg-rg-SE1328-Ab-1/ GM-Tg-rg-SE1328-Ab-2; GM-Tg-mg-SE1328-Ab-1/ GM-Tg-mg-SE1328-Ab-2; GM-Tg-cynog-SE1328-Ab-1/ GM-Tg-cynog-SE1328-Ab-2; GM-Tg-felg-SE1328-Ab-1/ GM-Tg-felg-SE1328-Ab-2; GM-Tg-cang-SE1328-Ab-1/ GM-Tg-cang-SE1328-Ab-2; GM-Tg-bovg-SE1328-Ab-1/ GM-Tg-bovg-SE1328-Ab-2; GM-Tg-equg-SE1328-Ab-1/ GM-Tg-equg-SE1328-Ab-2 |
| Products Name | Anti-TAC3 monoclonal antibody |
| Format | mab |
| Target Name | TAC3 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-TAC3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1328-Ag-1 | Recombinant multi-species TKNK/ TAC3/ HH10 protein |
| ORF Viral Vector | vGMLP000716 | human TAC3 Lentivirus particle |
| ORF Viral Vector | pGMLP000716 | human TAC3 Lentivirus plasmid |
Target information
| Target ID | GM-SE1328 |
| Target Name | TAC3 |
| Gene ID | 6866,21334,29191,713978,116183080,101089368,281513,100052673 |
| Gene Symbol and Synonyms | HH10,LncZBTB39,LOC116183080,NK3,NKB,NKNB,PPT-B,PRO1155,Tac2,TAC3,ZNEUROK1 |
| Uniprot Accession | Q9UHF0,P08435,P08858 |
| Uniprot Entry Name | TKNK_HUMAN,TKNK_RAT,TKNK_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000166863 |
| Target Classification | N/A |
The target: TAC3, gene name: TAC3, also named as HH10, NKB, NKNB, PRO1155, ZNEUROK1. This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded preproprotein is proteolytically processed to generate the mature peptide, which is primarily expressed in the central and peripheral nervous systems and functions as a neurotransmitter. This peptide is the ligand for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with normosmic hypogonadotropic hypogonadism. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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