Anti-TFF2/ SML1/ SP functional antibody

Anti-TFF2/ SML1/ SP functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to TFF2/TFF2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1333-Ab-1/ GM-Tg-hg-SE1333-Ab-2Anti-Human TFF2 monoclonal antibodyHuman
GM-Tg-rg-SE1333-Ab-1/ GM-Tg-rg-SE1333-Ab-2Anti-Rat TFF2 monoclonal antibodyRat
GM-Tg-mg-SE1333-Ab-1/ GM-Tg-mg-SE1333-Ab-2Anti-Mouse TFF2 monoclonal antibodyMouse
GM-Tg-cynog-SE1333-Ab-1/ GM-Tg-cynog-SE1333-Ab-2Anti-Cynomolgus/ Rhesus macaque TFF2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1333-Ab-1/ GM-Tg-felg-SE1333-Ab-2Anti-Feline TFF2 monoclonal antibodyFeline
GM-Tg-cang-SE1333-Ab-1/ GM-Tg-cang-SE1333-Ab-2Anti-Canine TFF2 monoclonal antibodyCanine
GM-Tg-bovg-SE1333-Ab-1/ GM-Tg-bovg-SE1333-Ab-2Anti-Bovine TFF2 monoclonal antibodyBovine
GM-Tg-equg-SE1333-Ab-1/ GM-Tg-equg-SE1333-Ab-2Anti-Equine TFF2 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1333-Ab-1/ GM-Tg-hg-SE1333-Ab-2; GM-Tg-rg-SE1333-Ab-1/ GM-Tg-rg-SE1333-Ab-2;
GM-Tg-mg-SE1333-Ab-1/ GM-Tg-mg-SE1333-Ab-2; GM-Tg-cynog-SE1333-Ab-1/ GM-Tg-cynog-SE1333-Ab-2;
GM-Tg-felg-SE1333-Ab-1/ GM-Tg-felg-SE1333-Ab-2; GM-Tg-cang-SE1333-Ab-1/ GM-Tg-cang-SE1333-Ab-2;
GM-Tg-bovg-SE1333-Ab-1/ GM-Tg-bovg-SE1333-Ab-2; GM-Tg-equg-SE1333-Ab-1/ GM-Tg-equg-SE1333-Ab-2
Products NameAnti-TFF2 monoclonal antibody
Formatmab
Target NameTFF2
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody, Diagnostic target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-TFF2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1333-Ag-1Recombinant multi-species TFF2/ SML1/ SP protein
    ORF Viral VectorpGMLP002301human TFF2 Lentivirus plasmid
    ORF Viral VectorvGMLP002301human TFF2 Lentivirus particle
    ORF Viral VectorpGMLPm000578mouse Tff2 Lentivirus plasmid
    ORF Viral VectorvGMLPm000578mouse Tff2 Lentivirus particle


    Target information

    Target IDGM-SE1333
    Target NameTFF2
    Gene ID7032,21785,116592,714550,403489,100170653,616105,100051351
    Gene Symbol and SynonymsmSP,SML1,SP,TFF2
    Uniprot AccessionQ03403,Q09030,Q863J2
    Uniprot Entry NameTFF2_HUMAN,TFF2_RAT,TFF2_CANLF
    Protein Sub-locationSecreted Protein/Potential Cytokines
    CategoryDiagnostics Biomarker
    DiseaseCancer
    Gene EnsemblENSG00000160181
    Target ClassificationTumor-associated antigen (TAA)

    The target: TFF2, gene name: TFF2, also named as SML1, SP. Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. The encoded protein inhibits gastric acid secretion. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.