- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-TSG6/ TNFAIP6/ TSG-6 functional antibody
Anti-TSG6/ TNFAIP6/ TSG-6 functional antibody for cell culture, ELISA & in-vivo assay
Go to TNFAIP6/TNFAIP6 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1343-Ab-1/ GM-Tg-hg-SE1343-Ab-2 | Anti-Human TNFAIP6 monoclonal antibody | Human |
| GM-Tg-rg-SE1343-Ab-1/ GM-Tg-rg-SE1343-Ab-2 | Anti-Rat TNFAIP6 monoclonal antibody | Rat |
| GM-Tg-mg-SE1343-Ab-1/ GM-Tg-mg-SE1343-Ab-2 | Anti-Mouse TNFAIP6 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1343-Ab-1/ GM-Tg-cynog-SE1343-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TNFAIP6 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1343-Ab-1/ GM-Tg-felg-SE1343-Ab-2 | Anti-Feline TNFAIP6 monoclonal antibody | Feline |
| GM-Tg-cang-SE1343-Ab-1/ GM-Tg-cang-SE1343-Ab-2 | Anti-Canine TNFAIP6 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1343-Ab-1/ GM-Tg-bovg-SE1343-Ab-2 | Anti-Bovine TNFAIP6 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1343-Ab-1/ GM-Tg-equg-SE1343-Ab-2 | Anti-Equine TNFAIP6 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1343-Ab-1/ GM-Tg-hg-SE1343-Ab-2; GM-Tg-rg-SE1343-Ab-1/ GM-Tg-rg-SE1343-Ab-2; GM-Tg-mg-SE1343-Ab-1/ GM-Tg-mg-SE1343-Ab-2; GM-Tg-cynog-SE1343-Ab-1/ GM-Tg-cynog-SE1343-Ab-2; GM-Tg-felg-SE1343-Ab-1/ GM-Tg-felg-SE1343-Ab-2; GM-Tg-cang-SE1343-Ab-1/ GM-Tg-cang-SE1343-Ab-2; GM-Tg-bovg-SE1343-Ab-1/ GM-Tg-bovg-SE1343-Ab-2; GM-Tg-equg-SE1343-Ab-1/ GM-Tg-equg-SE1343-Ab-2 |
| Products Name | Anti-TNFAIP6 monoclonal antibody |
| Format | mab |
| Target Name | TNFAIP6 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-TNFAIP6 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1343-Ag-1 | Recombinant multi-species TSG6/ TNFAIP6/ TSG-6 protein |
| Cytokine | GM-Tg-g-SE1343-Ag-1 | tumor necrosis factor, alpha-induced protein 6 (TNFAIP6) protein |
| ORF Viral Vector | pGMLP000090 | human TNFAIP6 Lentivirus plasmid |
| ORF Viral Vector | vGMLP000090 | human TNFAIP6 Lentivirus particle |
| ORF Viral Vector | pGMLPm003736 | mouse Tnfaip6 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003736 | mouse Tnfaip6 Lentivirus particle |
Target information
| Target ID | GM-SE1343 |
| Target Name | TNFAIP6 |
| Gene ID | 7130,21930,84397,694699,476147,101100655,493710,100034068 |
| Gene Symbol and Synonyms | TNFAIP6,Tnfip6,TSG-6,TSG6 |
| Uniprot Accession | P98066 |
| Uniprot Entry Name | TSG6_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Cytokine Target |
| Disease | Ovary Cancer |
| Gene Ensembl | ENSG00000123610 |
| Target Classification | N/A |
The target: TNFAIP6, gene name: TNFAIP6, also named as TSG-6, TSG6. The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.[provided by RefSeq, Dec 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
