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Anti-KCRU/ CKMT1B/ CKMT functional antibody
Anti-KCRU/ CKMT1B/ CKMT functional antibody for cell culture, ELISA & in-vivo assay
Go to CKMT1B/CKMT1B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1393-Ab-1/ GM-Tg-hg-SE1393-Ab-2 | Anti-Human CKMT1B monoclonal antibody | Human |
| GM-Tg-rg-SE1393-Ab-1/ GM-Tg-rg-SE1393-Ab-2 | Anti-Rat CKMT1B monoclonal antibody | Rat |
| GM-Tg-mg-SE1393-Ab-1/ GM-Tg-mg-SE1393-Ab-2 | Anti-Mouse CKMT1B monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1393-Ab-1/ GM-Tg-cynog-SE1393-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CKMT1B monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1393-Ab-1/ GM-Tg-felg-SE1393-Ab-2 | Anti-Feline CKMT1B monoclonal antibody | Feline |
| GM-Tg-cang-SE1393-Ab-1/ GM-Tg-cang-SE1393-Ab-2 | Anti-Canine CKMT1B monoclonal antibody | Canine |
| GM-Tg-bovg-SE1393-Ab-1/ GM-Tg-bovg-SE1393-Ab-2 | Anti-Bovine CKMT1B monoclonal antibody | Bovine |
| GM-Tg-equg-SE1393-Ab-1/ GM-Tg-equg-SE1393-Ab-2 | Anti-Equine CKMT1B monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1393-Ab-1/ GM-Tg-hg-SE1393-Ab-2; GM-Tg-rg-SE1393-Ab-1/ GM-Tg-rg-SE1393-Ab-2; GM-Tg-mg-SE1393-Ab-1/ GM-Tg-mg-SE1393-Ab-2; GM-Tg-cynog-SE1393-Ab-1/ GM-Tg-cynog-SE1393-Ab-2; GM-Tg-felg-SE1393-Ab-1/ GM-Tg-felg-SE1393-Ab-2; GM-Tg-cang-SE1393-Ab-1/ GM-Tg-cang-SE1393-Ab-2; GM-Tg-bovg-SE1393-Ab-1/ GM-Tg-bovg-SE1393-Ab-2; GM-Tg-equg-SE1393-Ab-1/ GM-Tg-equg-SE1393-Ab-2 |
| Products Name | Anti-CKMT1B monoclonal antibody |
| Format | mab |
| Target Name | CKMT1B |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CKMT1B benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1393-Ag-1 | Recombinant multi-species KCRU/ CKMT1B/ CKMT protein |
Target information
| Target ID | GM-SE1393 |
| Target Name | CKMT1B |
| Gene ID | 1159,12716,29593,101097983 |
| Gene Symbol and Synonyms | CKMT,CKMT1,CKMT1A,CKMT1B,mi-CK,mia-CK,Mt-CK,ScCKmit,U-MtCK,UbCKmit,UMTCK |
| Uniprot Accession | P12532,P25809 |
| Uniprot Entry Name | KCRU_HUMAN,KCRU_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000237289 |
| Target Classification | N/A |
The target: CKMT1B, gene name: CKMT1B, also named as CKMT, CKMT1, UMTCK. Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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