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Anti-ATG5/ APG5/ APG5-LIKE functional antibody
Anti-ATG5/ APG5/ APG5-LIKE functional antibody for cell culture, ELISA & in-vivo assay
Go to ATG5/ATG5 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1410-Ab-1/ GM-Tg-hg-SE1410-Ab-2 | Anti-Human ATG5 monoclonal antibody | Human |
| GM-Tg-rg-SE1410-Ab-1/ GM-Tg-rg-SE1410-Ab-2 | Anti-Rat ATG5 monoclonal antibody | Rat |
| GM-Tg-mg-SE1410-Ab-1/ GM-Tg-mg-SE1410-Ab-2 | Anti-Mouse ATG5 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1410-Ab-1/ GM-Tg-cynog-SE1410-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ATG5 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1410-Ab-1/ GM-Tg-felg-SE1410-Ab-2 | Anti-Feline ATG5 monoclonal antibody | Feline |
| GM-Tg-cang-SE1410-Ab-1/ GM-Tg-cang-SE1410-Ab-2 | Anti-Canine ATG5 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1410-Ab-1/ GM-Tg-bovg-SE1410-Ab-2 | Anti-Bovine ATG5 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1410-Ab-1/ GM-Tg-equg-SE1410-Ab-2 | Anti-Equine ATG5 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1410-Ab-1/ GM-Tg-hg-SE1410-Ab-2; GM-Tg-rg-SE1410-Ab-1/ GM-Tg-rg-SE1410-Ab-2; GM-Tg-mg-SE1410-Ab-1/ GM-Tg-mg-SE1410-Ab-2; GM-Tg-cynog-SE1410-Ab-1/ GM-Tg-cynog-SE1410-Ab-2; GM-Tg-felg-SE1410-Ab-1/ GM-Tg-felg-SE1410-Ab-2; GM-Tg-cang-SE1410-Ab-1/ GM-Tg-cang-SE1410-Ab-2; GM-Tg-bovg-SE1410-Ab-1/ GM-Tg-bovg-SE1410-Ab-2; GM-Tg-equg-SE1410-Ab-1/ GM-Tg-equg-SE1410-Ab-2 |
| Products Name | Anti-ATG5 monoclonal antibody |
| Format | mab |
| Target Name | ATG5 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ATG5 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1410-Ag-1 | Recombinant multi-species ATG5/ APG5/ APG5-LIKE protein |
| ORF Viral Vector | vGMLV000230 | human ATG5 Lentivirus particle |
| ORF Viral Vector | pGMLV000230 | human ATG5 Lentivirus plasmid |
| ORF Viral Vector | pGMLV000506 | human ATG5 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000506 | human ATG5 Lentivirus particle |
| ORF Viral Vector | pGMAD000032 | rat Atg5 Adenovirus plasmid |
| ORF Viral Vector | pGMAD000421 | Norway rat Atg5 Adenovirus plasmid |
| ORF Viral Vector | pGMAD000598 | house mouse Atg5 Adenovirus plasmid |
| ORF Viral Vector | pGMLPm000310 | mouse Atg5 Lentivirus plasmid |
| ORF Viral Vector | vGMAD000032 | rat Atg5 Adenovirus particle |
| ORF Viral Vector | vGMAD000421 | Norway rat Atg5 Adenovirus particle |
| ORF Viral Vector | vGMAD000598 | house mouse Atg5 Adenovirus particle |
| ORF Viral Vector | vGMLPm000310 | mouse Atg5 Lentivirus particle |
Target information
| Target ID | GM-SE1410 |
| Target Name | ATG5 |
| Gene ID | 9474,11793,365601,696874,610868,101092114,532686,100066344 |
| Gene Symbol and Synonyms | 2010107M05Rik,3110067M24Rik,APG5,APG5-LIKE,APG5L,ASP,ATG5,Atg5l,hAPG5,Paddy,SCAR25 |
| Uniprot Accession | Q9H1Y0,Q3MQ06,Q3MQ24 |
| Uniprot Entry Name | ATG5_HUMAN,ATG5_RAT,ATG5_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000057663 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: ATG5, gene name: ATG5, also named as APG5, APG5-LIKE, APG5L, ASP, SCAR25, hAPG5. The protein encoded by this gene, in combination with autophagy protein 12, functions as an E1-like activating enzyme in a ubiquitin-like conjugating system. The encoded protein is involved in several cellular processes, including autophagic vesicle formation, mitochondrial quality control after oxidative damage, negative regulation of the innate antiviral immune response, lymphocyte development and proliferation, MHC II antigen presentation, adipocyte differentiation, and apoptosis. Several transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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