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Anti-PAX2/ FSGS7/ PAPRS functional antibody
Anti-PAX2/ FSGS7/ PAPRS functional antibody for cell culture, ELISA & in-vivo assay
Go to PAX2/PAX2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1419-Ab-1/ GM-Tg-hg-SE1419-Ab-2 | Anti-Human PAX2 monoclonal antibody | Human |
| GM-Tg-rg-SE1419-Ab-1/ GM-Tg-rg-SE1419-Ab-2 | Anti-Rat PAX2 monoclonal antibody | Rat |
| GM-Tg-mg-SE1419-Ab-1/ GM-Tg-mg-SE1419-Ab-2 | Anti-Mouse PAX2 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1419-Ab-1/ GM-Tg-cynog-SE1419-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PAX2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1419-Ab-1/ GM-Tg-felg-SE1419-Ab-2 | Anti-Feline PAX2 monoclonal antibody | Feline |
| GM-Tg-cang-SE1419-Ab-1/ GM-Tg-cang-SE1419-Ab-2 | Anti-Canine PAX2 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1419-Ab-1/ GM-Tg-bovg-SE1419-Ab-2 | Anti-Bovine PAX2 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1419-Ab-1/ GM-Tg-equg-SE1419-Ab-2 | Anti-Equine PAX2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1419-Ab-1/ GM-Tg-hg-SE1419-Ab-2; GM-Tg-rg-SE1419-Ab-1/ GM-Tg-rg-SE1419-Ab-2; GM-Tg-mg-SE1419-Ab-1/ GM-Tg-mg-SE1419-Ab-2; GM-Tg-cynog-SE1419-Ab-1/ GM-Tg-cynog-SE1419-Ab-2; GM-Tg-felg-SE1419-Ab-1/ GM-Tg-felg-SE1419-Ab-2; GM-Tg-cang-SE1419-Ab-1/ GM-Tg-cang-SE1419-Ab-2; GM-Tg-bovg-SE1419-Ab-1/ GM-Tg-bovg-SE1419-Ab-2; GM-Tg-equg-SE1419-Ab-1/ GM-Tg-equg-SE1419-Ab-2 |
| Products Name | Anti-PAX2 monoclonal antibody |
| Format | mab |
| Target Name | PAX2 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PAX2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1419-Ag-1 | Recombinant multi-species PAX2/ FSGS7/ PAPRS protein |
| ORF Viral Vector | vGMLP003692 | human PAX2 Lentivirus particle |
| ORF Viral Vector | pGMLP003692 | human PAX2 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm004367 | mouse Pax2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004367 | mouse Pax2 Lentivirus particle |
Target information
| Target ID | GM-SE1419 |
| Target Name | PAX2 |
| Gene ID | 5076,18504,293992,710687,609228,101092147,100297382,100070326 |
| Gene Symbol and Synonyms | FSGS7,Opdc,PAPRS,PAX-2,PAX2 |
| Uniprot Accession | Q02962 |
| Uniprot Entry Name | PAX2_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000075891 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: PAX2, gene name: PAX2, also named as FSGS7, PAPRS. PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is believed to be a target of transcriptional supression by the tumor suppressor gene WT1. Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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