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Anti-MSH3/ DUP/ FAP4 functional antibody
Anti-MSH3/ DUP/ FAP4 functional antibody for cell culture, ELISA & in-vivo assay
Go to MSH3/MSH3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1464-Ab-1/ GM-Tg-hg-SE1464-Ab-2 | Anti-Human MSH3 monoclonal antibody | Human |
| GM-Tg-rg-SE1464-Ab-1/ GM-Tg-rg-SE1464-Ab-2 | Anti-Rat MSH3 monoclonal antibody | Rat |
| GM-Tg-mg-SE1464-Ab-1/ GM-Tg-mg-SE1464-Ab-2 | Anti-Mouse MSH3 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1464-Ab-1/ GM-Tg-cynog-SE1464-Ab-2 | Anti-Cynomolgus/ Rhesus macaque MSH3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1464-Ab-1/ GM-Tg-felg-SE1464-Ab-2 | Anti-Feline MSH3 monoclonal antibody | Feline |
| GM-Tg-cang-SE1464-Ab-1/ GM-Tg-cang-SE1464-Ab-2 | Anti-Canine MSH3 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1464-Ab-1/ GM-Tg-bovg-SE1464-Ab-2 | Anti-Bovine MSH3 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1464-Ab-1/ GM-Tg-equg-SE1464-Ab-2 | Anti-Equine MSH3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1464-Ab-1/ GM-Tg-hg-SE1464-Ab-2; GM-Tg-rg-SE1464-Ab-1/ GM-Tg-rg-SE1464-Ab-2; GM-Tg-mg-SE1464-Ab-1/ GM-Tg-mg-SE1464-Ab-2; GM-Tg-cynog-SE1464-Ab-1/ GM-Tg-cynog-SE1464-Ab-2; GM-Tg-felg-SE1464-Ab-1/ GM-Tg-felg-SE1464-Ab-2; GM-Tg-cang-SE1464-Ab-1/ GM-Tg-cang-SE1464-Ab-2; GM-Tg-bovg-SE1464-Ab-1/ GM-Tg-bovg-SE1464-Ab-2; GM-Tg-equg-SE1464-Ab-1/ GM-Tg-equg-SE1464-Ab-2 |
| Products Name | Anti-MSH3 monoclonal antibody |
| Format | mab |
| Target Name | MSH3 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-MSH3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1464-Ag-1 | Recombinant multi-species MSH3/ DUP/ FAP4 protein |
| ORF Viral Vector | pGMLPm003901 | mouse Msh3 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003901 | mouse Msh3 Lentivirus particle |
Target information
| Target ID | GM-SE1464 |
| Target Name | MSH3 |
| Gene ID | 4437,17686,499505,711187,479164,101090919,616744,100073255 |
| Gene Symbol and Synonyms | D13Em1,DUP,FAP4,MRP1,MSH3,REP-1,Rep-3,Rep3 |
| Uniprot Accession | P20585 |
| Uniprot Entry Name | MSH3_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000113318 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: MSH3, gene name: MSH3, also named as DUP, FAP4, MRP1. The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer. [provided by RefSeq, Mar 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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