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Anti-CASQ2/ PDIB2 functional antibody
Anti-CASQ2/ PDIB2 functional antibody for cell culture, ELISA & in-vivo assay
Go to CASQ2/CASQ2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1474-Ab-1/ GM-Tg-hg-SE1474-Ab-2 | Anti-Human CASQ2 monoclonal antibody | Human |
| GM-Tg-rg-SE1474-Ab-1/ GM-Tg-rg-SE1474-Ab-2 | Anti-Rat CASQ2 monoclonal antibody | Rat |
| GM-Tg-mg-SE1474-Ab-1/ GM-Tg-mg-SE1474-Ab-2 | Anti-Mouse CASQ2 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1474-Ab-1/ GM-Tg-cynog-SE1474-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CASQ2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1474-Ab-1/ GM-Tg-felg-SE1474-Ab-2 | Anti-Feline CASQ2 monoclonal antibody | Feline |
| GM-Tg-cang-SE1474-Ab-1/ GM-Tg-cang-SE1474-Ab-2 | Anti-Canine CASQ2 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1474-Ab-1/ GM-Tg-bovg-SE1474-Ab-2 | Anti-Bovine CASQ2 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1474-Ab-1/ GM-Tg-equg-SE1474-Ab-2 | Anti-Equine CASQ2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1474-Ab-1/ GM-Tg-hg-SE1474-Ab-2; GM-Tg-rg-SE1474-Ab-1/ GM-Tg-rg-SE1474-Ab-2; GM-Tg-mg-SE1474-Ab-1/ GM-Tg-mg-SE1474-Ab-2; GM-Tg-cynog-SE1474-Ab-1/ GM-Tg-cynog-SE1474-Ab-2; GM-Tg-felg-SE1474-Ab-1/ GM-Tg-felg-SE1474-Ab-2; GM-Tg-cang-SE1474-Ab-1/ GM-Tg-cang-SE1474-Ab-2; GM-Tg-bovg-SE1474-Ab-1/ GM-Tg-bovg-SE1474-Ab-2; GM-Tg-equg-SE1474-Ab-1/ GM-Tg-equg-SE1474-Ab-2 |
| Products Name | Anti-CASQ2 monoclonal antibody |
| Format | mab |
| Target Name | CASQ2 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CASQ2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1474-Ag-1 | Recombinant multi-species CASQ2/ PDIB2 protein |
| ORF Viral Vector | vGMLP002728 | human CASQ2 Lentivirus particle |
| ORF Viral Vector | pGMLP002728 | human CASQ2 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm005262 | mouse Casq2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005262 | mouse Casq2 Lentivirus particle |
Target information
| Target ID | GM-SE1474 |
| Target Name | CASQ2 |
| Gene ID | 845,12373,29209,712373,483134,101082678,528555,100059622 |
| Gene Symbol and Synonyms | CAL,cardCSQ,CASQ2,cCSQ,Csq2,ES™52,PDIB2 |
| Uniprot Accession | O14958,P51868,P12637 |
| Uniprot Entry Name | CASQ2_HUMAN,CASQ2_RAT,CASQ2_CANLF |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000118729 |
| Target Classification | N/A |
The target: CASQ2, gene name: CASQ2, also named as PDIB2. The protein encoded by this gene specifies the cardiac muscle family member of the calsequestrin family. Calsequestrin is localized to the sarcoplasmic reticulum in cardiac and slow skeletal muscle cells. The protein is a calcium binding protein that stores calcium for muscle function. Mutations in this gene cause stress-induced polymorphic ventricular tachycardia, also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), a disease characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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