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Anti-BMAL1/ ARNTL/ BMAL1c functional antibody
Anti-BMAL1/ ARNTL/ BMAL1c functional antibody for cell culture, ELISA & in-vivo assay
Go to ARNTL/ARNTL products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1499-Ab-1/ GM-Tg-hg-SE1499-Ab-2 | Anti-Human ARNTL monoclonal antibody | Human |
| GM-Tg-rg-SE1499-Ab-1/ GM-Tg-rg-SE1499-Ab-2 | Anti-Rat ARNTL monoclonal antibody | Rat |
| GM-Tg-mg-SE1499-Ab-1/ GM-Tg-mg-SE1499-Ab-2 | Anti-Mouse ARNTL monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1499-Ab-1/ GM-Tg-cynog-SE1499-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ARNTL monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1499-Ab-1/ GM-Tg-felg-SE1499-Ab-2 | Anti-Feline ARNTL monoclonal antibody | Feline |
| GM-Tg-cang-SE1499-Ab-1/ GM-Tg-cang-SE1499-Ab-2 | Anti-Canine ARNTL monoclonal antibody | Canine |
| GM-Tg-bovg-SE1499-Ab-1/ GM-Tg-bovg-SE1499-Ab-2 | Anti-Bovine ARNTL monoclonal antibody | Bovine |
| GM-Tg-equg-SE1499-Ab-1/ GM-Tg-equg-SE1499-Ab-2 | Anti-Equine ARNTL monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1499-Ab-1/ GM-Tg-hg-SE1499-Ab-2; GM-Tg-rg-SE1499-Ab-1/ GM-Tg-rg-SE1499-Ab-2; GM-Tg-mg-SE1499-Ab-1/ GM-Tg-mg-SE1499-Ab-2; GM-Tg-cynog-SE1499-Ab-1/ GM-Tg-cynog-SE1499-Ab-2; GM-Tg-felg-SE1499-Ab-1/ GM-Tg-felg-SE1499-Ab-2; GM-Tg-cang-SE1499-Ab-1/ GM-Tg-cang-SE1499-Ab-2; GM-Tg-bovg-SE1499-Ab-1/ GM-Tg-bovg-SE1499-Ab-2; GM-Tg-equg-SE1499-Ab-1/ GM-Tg-equg-SE1499-Ab-2 |
| Products Name | Anti-ARNTL monoclonal antibody |
| Format | mab |
| Target Name | ARNTL |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ARNTL benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1499-Ag-1 | Recombinant multi-species BMAL1/ ARNTL/ BMAL1c protein |
| ORF Viral Vector | pGMAD000559 | house mouse Arntl Adenovirus plasmid |
| ORF Viral Vector | pGMLV000802 | house mouse Arntl Lentivirus plasmid |
| ORF Viral Vector | vGMLV000802 | house mouse Arntl Lentivirus particle |
| ORF Viral Vector | vGMAD000531 | house mouse Arntl Adenovirus particle |
| ORF Viral Vector | vGMAD000559 | house mouse Arntl Adenovirus particle |
Target information
| Target ID | GM-SE1499 |
| Target Name | ARNTL |
| Gene ID | 406,11865,29657,700464,476860,101091727,530705,100034115 |
| Gene Symbol and Synonyms | Arnt3,ARNTL,ARNTL1,bHLHe5,BMAL1,BMAL1b,bmal1b',BMAL1c,JAP3,MOP3,PASD3,TIC |
| Uniprot Accession | O00327,Q9EPW1,A0MLS5 |
| Uniprot Entry Name | BMAL1_HUMAN,BMAL1_RAT,BMAL1_HORSE |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000133794 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: ARNTL, gene name: ARNTL, also named as BMAL1, BMAL1c, JAP3, MOP3, PASD3, TIC, bHLHe5. The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. The protein regulates interferon-stimulated gene expression and is an important factor in viral infection, including COVID-19. [provided by RefSeq, Oct 2021].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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