Anti-CASQ1/ CASQ/ PDIB1 functional antibody

Anti-CASQ1/ CASQ/ PDIB1 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to CASQ1/CASQ1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1523-Ab-1/ GM-Tg-hg-SE1523-Ab-2Anti-Human CASQ1 monoclonal antibodyHuman
GM-Tg-rg-SE1523-Ab-1/ GM-Tg-rg-SE1523-Ab-2Anti-Rat CASQ1 monoclonal antibodyRat
GM-Tg-mg-SE1523-Ab-1/ GM-Tg-mg-SE1523-Ab-2Anti-Mouse CASQ1 monoclonal antibodyMouse
GM-Tg-cynog-SE1523-Ab-1/ GM-Tg-cynog-SE1523-Ab-2Anti-Cynomolgus/ Rhesus macaque CASQ1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1523-Ab-1/ GM-Tg-felg-SE1523-Ab-2Anti-Feline CASQ1 monoclonal antibodyFeline
GM-Tg-cang-SE1523-Ab-1/ GM-Tg-cang-SE1523-Ab-2Anti-Canine CASQ1 monoclonal antibodyCanine
GM-Tg-bovg-SE1523-Ab-1/ GM-Tg-bovg-SE1523-Ab-2Anti-Bovine CASQ1 monoclonal antibodyBovine
GM-Tg-equg-SE1523-Ab-1/ GM-Tg-equg-SE1523-Ab-2Anti-Equine CASQ1 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1523-Ab-1/ GM-Tg-hg-SE1523-Ab-2; GM-Tg-rg-SE1523-Ab-1/ GM-Tg-rg-SE1523-Ab-2;
GM-Tg-mg-SE1523-Ab-1/ GM-Tg-mg-SE1523-Ab-2; GM-Tg-cynog-SE1523-Ab-1/ GM-Tg-cynog-SE1523-Ab-2;
GM-Tg-felg-SE1523-Ab-1/ GM-Tg-felg-SE1523-Ab-2; GM-Tg-cang-SE1523-Ab-1/ GM-Tg-cang-SE1523-Ab-2;
GM-Tg-bovg-SE1523-Ab-1/ GM-Tg-bovg-SE1523-Ab-2; GM-Tg-equg-SE1523-Ab-1/ GM-Tg-equg-SE1523-Ab-2
Products NameAnti-CASQ1 monoclonal antibody
Formatmab
Target NameCASQ1
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CASQ1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1523-Ag-1Recombinant multi-species CASQ1/ CASQ/ PDIB1 protein
    ORF Viral VectorvGMLP001375human CASQ1 Lentivirus particle
    ORF Viral VectorpGMLP001375human CASQ1 Lentivirus plasmid
    ORF Viral VectorpGMLPm001649mouse Casq1 Lentivirus plasmid
    ORF Viral VectorvGMLPm001649mouse Casq1 Lentivirus particle


    Target information

    Target IDGM-SE1523
    Target NameCASQ1
    Gene ID844,12372,686019,720233,608401,101091082,508394,100058343
    Gene Symbol and SynonymsCASQ,CASQ1,CSQ,CSQ-1,CSQ1,PDIB1,sCSQ,VMCQA
    Uniprot AccessionP31415,P19633,P31236
    Uniprot Entry NameCASQ1_HUMAN,CASQ1_RAT,CASQ1_CANLF
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000143318
    Target ClassificationN/A

    The target: CASQ1, gene name: CASQ1, also named as CASQ, PDIB1, VMCQA. This gene encodes the skeletal muscle specific member of the calsequestrin protein family. Calsequestrin functions as a luminal sarcoplasmic reticulum calcium sensor in both cardiac and skeletal muscle cells. This protein, also known as calmitine, functions as a calcium regulator in the mitochondria of skeletal muscle. This protein is absent in patients with Duchenne and Becker types of muscular dystrophy. [provided by RefSeq, Jun 2013].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.