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Anti-KAD4/ AK4/ AK 4 functional antibody
Anti-KAD4/ AK4/ AK 4 functional antibody for cell culture, ELISA & in-vivo assay
Go to AK4/AK4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1556-Ab-1/ GM-Tg-hg-SE1556-Ab-2 | Anti-Human AK4 monoclonal antibody | Human |
| GM-Tg-rg-SE1556-Ab-1/ GM-Tg-rg-SE1556-Ab-2 | Anti-Rat AK4 monoclonal antibody | Rat |
| GM-Tg-mg-SE1556-Ab-1/ GM-Tg-mg-SE1556-Ab-2 | Anti-Mouse AK4 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1556-Ab-1/ GM-Tg-cynog-SE1556-Ab-2 | Anti-Cynomolgus/ Rhesus macaque AK4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1556-Ab-1/ GM-Tg-felg-SE1556-Ab-2 | Anti-Feline AK4 monoclonal antibody | Feline |
| GM-Tg-cang-SE1556-Ab-1/ GM-Tg-cang-SE1556-Ab-2 | Anti-Canine AK4 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1556-Ab-1/ GM-Tg-bovg-SE1556-Ab-2 | Anti-Bovine AK4 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1556-Ab-1/ GM-Tg-equg-SE1556-Ab-2 | Anti-Equine AK4 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1556-Ab-1/ GM-Tg-hg-SE1556-Ab-2; GM-Tg-rg-SE1556-Ab-1/ GM-Tg-rg-SE1556-Ab-2; GM-Tg-mg-SE1556-Ab-1/ GM-Tg-mg-SE1556-Ab-2; GM-Tg-cynog-SE1556-Ab-1/ GM-Tg-cynog-SE1556-Ab-2; GM-Tg-felg-SE1556-Ab-1/ GM-Tg-felg-SE1556-Ab-2; GM-Tg-cang-SE1556-Ab-1/ GM-Tg-cang-SE1556-Ab-2; GM-Tg-bovg-SE1556-Ab-1/ GM-Tg-bovg-SE1556-Ab-2; GM-Tg-equg-SE1556-Ab-1/ GM-Tg-equg-SE1556-Ab-2 |
| Products Name | Anti-AK4 monoclonal antibody |
| Format | mab |
| Target Name | AK4 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-AK4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1556-Ag-1 | Recombinant multi-species KAD4/ AK4/ AK 4 protein |
| ORF Viral Vector | vGMLP002502 | 0 AK4 Lentivirus particle |
| ORF Viral Vector | pGMLP002502 | human AK4 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm000782 | mouse Ak4 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000782 | mouse Ak4 Lentivirus particle |
Target information
| Target ID | GM-SE1556 |
| Target Name | AK4 |
| Gene ID | 205,11639,29223,698560,489554,101084638,517063,100069665 |
| Gene Symbol and Synonyms | AK 4,Ak-3,Ak-4,AK3,AK3L1,AK3L2,AK4,D4Ertd274e |
| Uniprot Accession | P27144,Q9WUS0,Q0VCP1 |
| Uniprot Entry Name | KAD4_HUMAN,KAD4_RAT,KAD4_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000162433 |
| Target Classification | N/A |
The target: AK4, gene name: AK4, also named as AK 4, AK3, AK3L1, AK3L2. This gene encodes a member of the adenylate kinase family of enzymes. The encoded protein is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. A pseudogene for this gene has been located on chromosome 17. Three transcript variants encoding the same protein have been identified for this gene. Sequence alignment suggests that the gene defined by NM_013410, NM_203464, and NM_001005353 is located on chromosome 1. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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