Anti-CEP57/ MVA2/ PIG8 functional antibody

Anti-CEP57/ MVA2/ PIG8 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to CEP57/CEP57 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1572-Ab-1/ GM-Tg-hg-SE1572-Ab-2Anti-Human CEP57 monoclonal antibodyHuman
GM-Tg-rg-SE1572-Ab-1/ GM-Tg-rg-SE1572-Ab-2Anti-Rat CEP57 monoclonal antibodyRat
GM-Tg-mg-SE1572-Ab-1/ GM-Tg-mg-SE1572-Ab-2Anti-Mouse CEP57 monoclonal antibodyMouse
GM-Tg-cynog-SE1572-Ab-1/ GM-Tg-cynog-SE1572-Ab-2Anti-Cynomolgus/ Rhesus macaque CEP57 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1572-Ab-1/ GM-Tg-felg-SE1572-Ab-2Anti-Feline CEP57 monoclonal antibodyFeline
GM-Tg-cang-SE1572-Ab-1/ GM-Tg-cang-SE1572-Ab-2Anti-Canine CEP57 monoclonal antibodyCanine
GM-Tg-bovg-SE1572-Ab-1/ GM-Tg-bovg-SE1572-Ab-2Anti-Bovine CEP57 monoclonal antibodyBovine
GM-Tg-equg-SE1572-Ab-1/ GM-Tg-equg-SE1572-Ab-2Anti-Equine CEP57 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1572-Ab-1/ GM-Tg-hg-SE1572-Ab-2; GM-Tg-rg-SE1572-Ab-1/ GM-Tg-rg-SE1572-Ab-2;
GM-Tg-mg-SE1572-Ab-1/ GM-Tg-mg-SE1572-Ab-2; GM-Tg-cynog-SE1572-Ab-1/ GM-Tg-cynog-SE1572-Ab-2;
GM-Tg-felg-SE1572-Ab-1/ GM-Tg-felg-SE1572-Ab-2; GM-Tg-cang-SE1572-Ab-1/ GM-Tg-cang-SE1572-Ab-2;
GM-Tg-bovg-SE1572-Ab-1/ GM-Tg-bovg-SE1572-Ab-2; GM-Tg-equg-SE1572-Ab-1/ GM-Tg-equg-SE1572-Ab-2
Products NameAnti-CEP57 monoclonal antibody
Formatmab
Target NameCEP57
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CEP57 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1572-Ag-1Recombinant multi-species CEP57/ MVA2/ PIG8 protein
    ORF Viral VectorvGMLP001070human CEP57 Lentivirus particle
    ORF Viral VectorpGMLP001070human CEP57 Lentivirus plasmid
    ORF Viral VectorpGMLPm003158mouse Cep57 Lentivirus plasmid
    ORF Viral VectorvGMLPm003158mouse Cep57 Lentivirus particle


    Target information

    Target IDGM-SE1572
    Target NameCEP57
    Gene ID9702,74360,315423,699835,476766,101084902,353245,100067852
    Gene Symbol and Synonyms3110002L15Rik,4921510P06Rik,4931428M20Rik,CEP57,mKIAA0092,MVA2,PIG8,RGD1309884,TSP57
    Uniprot AccessionQ86XR8,B4F7A7,Q865V0
    Uniprot Entry NameCEP57_HUMAN,CEP57_RAT,CEP57_BOVIN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000166037
    Target ClassificationN/A

    The target: CEP57, gene name: CEP57, also named as MVA2, PIG8, TSP57. This gene encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.