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Anti-CSN6/ COPS6/ MOV34-34KD functional antibody
Anti-CSN6/ COPS6/ MOV34-34KD functional antibody for cell culture, ELISA & in-vivo assay
Go to COPS6/COPS6 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1586-Ab-1/ GM-Tg-hg-SE1586-Ab-2 | Anti-Human COPS6 monoclonal antibody | Human |
| GM-Tg-rg-SE1586-Ab-1/ GM-Tg-rg-SE1586-Ab-2 | Anti-Rat COPS6 monoclonal antibody | Rat |
| GM-Tg-mg-SE1586-Ab-1/ GM-Tg-mg-SE1586-Ab-2 | Anti-Mouse COPS6 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1586-Ab-1/ GM-Tg-cynog-SE1586-Ab-2 | Anti-Cynomolgus/ Rhesus macaque COPS6 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1586-Ab-1/ GM-Tg-felg-SE1586-Ab-2 | Anti-Feline COPS6 monoclonal antibody | Feline |
| GM-Tg-cang-SE1586-Ab-1/ GM-Tg-cang-SE1586-Ab-2 | Anti-Canine COPS6 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1586-Ab-1/ GM-Tg-bovg-SE1586-Ab-2 | Anti-Bovine COPS6 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1586-Ab-1/ GM-Tg-equg-SE1586-Ab-2 | Anti-Equine COPS6 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1586-Ab-1/ GM-Tg-hg-SE1586-Ab-2; GM-Tg-rg-SE1586-Ab-1/ GM-Tg-rg-SE1586-Ab-2; GM-Tg-mg-SE1586-Ab-1/ GM-Tg-mg-SE1586-Ab-2; GM-Tg-cynog-SE1586-Ab-1/ GM-Tg-cynog-SE1586-Ab-2; GM-Tg-felg-SE1586-Ab-1/ GM-Tg-felg-SE1586-Ab-2; GM-Tg-cang-SE1586-Ab-1/ GM-Tg-cang-SE1586-Ab-2; GM-Tg-bovg-SE1586-Ab-1/ GM-Tg-bovg-SE1586-Ab-2; GM-Tg-equg-SE1586-Ab-1/ GM-Tg-equg-SE1586-Ab-2 |
| Products Name | Anti-COPS6 monoclonal antibody |
| Format | mab |
| Target Name | COPS6 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-COPS6 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1586-Ag-1 | Recombinant multi-species CSN6/ COPS6/ MOV34-34KD protein |
| ORF Viral Vector | vGMLP000698 | human COPS6 Lentivirus particle |
| ORF Viral Vector | pGMLP000698 | human COPS6 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm002597 | mouse Cops6 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002597 | mouse Cops6 Lentivirus particle |
Target information
| Target ID | GM-SE1586 |
| Target Name | COPS6 |
| Gene ID | 10980,26893,304343,710667,119872152,101088133,512756,100068657 |
| Gene Symbol and Synonyms | COPS6,CSN6,MOV34-34KD,Sgn3,VIP/MOV34 |
| Uniprot Accession | Q7L5N1,A6QQ21 |
| Uniprot Entry Name | CSN6_HUMAN,CSN6_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000168090 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: COPS6, gene name: COPS6, also named as CSN6, MOV34-34KD. The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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